Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1760645..1762340 Replicon chromosome
Accession NZ_CP046060
Organism Pseudomonas aeruginosa strain 1811-18R001

Toxin (Protein)


Gene name doc Uniprot ID A0A1C7C456
Locus tag GJV02_RS08280 Protein ID WP_022579703.1
Coordinates 1760645..1761514 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1C7C9F9
Locus tag GJV02_RS08285 Protein ID WP_017001846.1
Coordinates 1761507..1762340 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJV02_RS08255 1756654..1757505 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
GJV02_RS08260 1757545..1758552 + 1008 WP_023108660.1 ABC transporter substrate-binding protein -
GJV02_RS08265 1758549..1759325 + 777 WP_003112898.1 ABC transporter permease -
GJV02_RS08270 1759331..1760092 + 762 WP_023106074.1 SDR family oxidoreductase -
GJV02_RS08275 1760106..1760636 + 531 WP_003112900.1 cupin domain-containing protein -
GJV02_RS08280 1760645..1761514 + 870 WP_022579703.1 alpha/beta hydrolase Toxin
GJV02_RS08285 1761507..1762340 + 834 WP_017001846.1 IclR family transcriptional regulator Antitoxin
GJV02_RS08290 1762327..1763124 + 798 WP_003112903.1 SDR family oxidoreductase -
GJV02_RS08295 1763117..1764799 + 1683 WP_031692523.1 thiamine pyrophosphate-binding protein -
GJV02_RS08300 1764810..1765613 + 804 WP_003112905.1 aspartate dehydrogenase -
GJV02_RS08305 1765625..1767109 + 1485 WP_017001843.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30389.65 Da        Isoelectric Point: 6.8139

>T143486 WP_022579703.1 NZ_CP046060:1760645-1761514 [Pseudomonas aeruginosa]
MNMAQTHIPAPSLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAARLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSPIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

>T143486 NZ_CP061109:c5488-5213 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATTTGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30867.22 Da        Isoelectric Point: 5.7725

>AT143486 WP_017001846.1 NZ_CP046060:1761507-1762340 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRSHETV

Download         Length: 834 bp

>AT143486 NZ_CP061109:c5772-5488 [Escherichia coli]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7C456

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C9F9

References