Detailed information of TA system TA143485

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 142133..142638
• Replicon: chromosome
• Accession: NZ_CP046060
• Organism: Pseudomonas aeruginosa strain 1811-18R001

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: GJV02_RS00650
• Protein ID: WP_003083773.1
• Coordinates: 142133..142414 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: GJV02_RS00655
• Protein ID: WP_003083775.1
• Coordinates: 142411..142638 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJV02_RS00625	137384..138733	+	1350	WP_003119513.1	C4-dicarboxylate transporter DctA	-
GJV02_RS00630	138782..139468	+	687	WP_003083762.1	FadR family transcriptional regulator	-
GJV02_RS00635	139569..140303	+	735	WP_003117208.1	GntR family transcriptional regulator	-
GJV02_RS00640	140507..140893	+	387	WP_003083767.1	aegerolysin family protein	-
GJV02_RS00645	140925..141833	-	909	WP_003083769.1	LysR family transcriptional regulator	-
GJV02_RS00650	142133..142414	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
GJV02_RS00655	142411..142638	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
GJV02_RS00660	142814..143434	-	621	WP_031298866.1	hypothetical protein	-
GJV02_RS00665	143535..144035	+	501	WP_003101228.1	LEA type 2 family protein	-
GJV02_RS00670	144108..144449	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
GJV02_RS00675	144531..145958	-	1428	WP_023464187.1	GABA permease	-
GJV02_RS00680	146127..147620	-	1494	WP_016263977.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T143485 WP_003083773.1 NZ_CP046060:c142414-142133 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T143485 NZ_CP061108:c4448296-4447748 [Escherichia coli]
ATGTCTCATAATTCAGATATCTATAAACTGATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAGCAGGCTTTTGAATCCGCATTTGAGCCGTCTAATCATGAACGCGATGATGATTCTTCTTCAG
AAAATAAGGCTATTCTGGAGGAAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTCCGGACAAAAATGGCATCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTCGTTGTCGCAATGTTTA
CATCGTTTCTTATTGCACATGAAGGAAAGGCTCCAGTTGAAGCGATCGTTGCATTACTAGGTACAAGTACAATTAGTATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATAGTGATAAAGAAAAATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT143485 WP_003083775.1 NZ_CP046060:c142638-142411 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT143485 NZ_CP061108:c4448792-4448319 [Escherichia coli]
ATGTACAGTCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAATGAATGTGTCTCCGCGT
GGAAGTACGGTCCAGTTATTCCTGGAATGTACGATGCTTTCAAAGACTATGGGAATAAACCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATCGTTACTATGGATCCGCAAGCAGAGAGCATTATCGGGGCTGTTTATAAGTTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCGA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9