Detailed information of TA system TA143482

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 2301897..2302303
• Replicon: chromosome
• Accession: NZ_CP046058
• Organism: Microcystis aeruginosa NIES-298

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A3N0VX23
• Locus tag: D3800_RS11015
• Protein ID: WP_024968900.1
• Coordinates: 2301897..2302094 (+)
• Length: 66 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: D3800_RS11020
• Protein ID: WP_103111495.1
• Coordinates: 2302094..2302303 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D3800_RS11000	2299338..2299955	-	618	WP_103111493.1	7-carboxy-7-deazaguanine synthase QueE	-
D3800_RS11005	2299932..2300489	+	558	WP_103111576.1	Ycf51 family protein	-
D3800_RS11010	2300509..2301618	+	1110	WP_103111494.1	iron-containing alcohol dehydrogenase family protein	-
D3800_RS11015	2301897..2302094	+	198	WP_024968900.1	type II toxin-antitoxin system HicA family toxin	Toxin
D3800_RS11020	2302094..2302303	+	210	WP_103111495.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
D3800_RS11025	2302314..2302424	+	111	Protein_2186	type II toxin-antitoxin system HigB family toxin	-
D3800_RS11030	2302429..2302650	+	222	WP_103111496.1	hypothetical protein	-
D3800_RS11035	2302972..2304105	+	1134	WP_103111497.1	HetZ-related protein 2	-
D3800_RS23985	2304216..2304374	+	159	WP_002776561.1	hypothetical protein	-
D3800_RS11040	2304377..2305891	+	1515	WP_103111498.1	cryptochrome/photolyase family protein	-
D3800_RS11045	2306007..2306348	+	342	WP_002750167.1	translation initiation factor	-
D3800_RS11050	2306358..2306825	+	468	WP_002739978.1	TspO/MBR family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-65)

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7350.47 Da
• Isoelectric Point: 10.6627

>T143482 WP_024968900.1 NZ_CP046058:2301897-2302094 [Microcystis aeruginosa NIES-298]
MKVKQVIKVLEADGWYLARTRGSHRQYKHPSKSGTVTVSGKSSVDVPIGTLKNIWRQAQIEEDKI

Nucleotide

• Length: 198 bp

>T143482 NZ_CP061108:3535462-3535680 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7425.52 Da
• Isoelectric Point: 3.8950

>AT143482 WP_103111495.1 NZ_CP046058:2302094-2302303 [Microcystis aeruginosa NIES-298]
MRYAVVIEKGENSYGAYVPDLPGCVAVAETLEEVKQLIAEAIIFHLEGLKEDGLTVPESVSICECVDVA

Nucleotide

• Length: 210 bp

>AT143482 NZ_CP061108:3535062-3535436 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A3N0VX23