Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1768848..1769629 Replicon chromosome
Accession NZ_CP046058
Organism Microcystis aeruginosa NIES-298

Toxin (Protein)


Gene name TacT2 Uniprot ID I4GLQ9
Locus tag D3800_RS08540 Protein ID WP_002778801.1
Coordinates 1768848..1769342 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID I4GLR0
Locus tag D3800_RS08545 Protein ID WP_002778803.1
Coordinates 1769339..1769629 (-) Length 97 a.a.

Genomic Context

D3800_RS08525D3800_RS08530D3800_RS08535D3800_RS08575D3800_RS08580D3800_RS08520D3800_RS08540D3800_RS08545D3800_RS08550D3800_RS08555D3800_RS08560D3800_RS08565D3800_RS08570D3800_RS08585D3800_RS08590
Location: 1766769..1767617 (849 bp)
Type: Others
Protein ID: WP_002738738.1
Location: 1767843..1768217 (375 bp)
Type: Others
Protein ID: Protein_1692
Location: 1768214..1768696 (483 bp)
Type: Others
Protein ID: WP_002738740.1
Location: 1772652..1772978 (327 bp)
Type: Others
Protein ID: WP_202861585.1
Location: 1772975..1773190 (216 bp)
Type: Others
Protein ID: WP_002757627.1
Location: 1765277..1766659 (1383 bp)
Type: Others
Protein ID: WP_103112833.1
Location: 1768848..1769342 (495 bp)
Type: Toxin
Protein ID: WP_002778801.1
Location: 1769339..1769629 (291 bp)
Type: Antitoxin
Protein ID: WP_002778803.1
Location: 1769894..1770166 (273 bp)
Type: Others
Protein ID: WP_002799473.1
Location: 1770144..1770431 (288 bp)
Type: Others
Protein ID: Protein_1697
Location: 1770659..1771156 (498 bp)
Type: Others
Protein ID: WP_103112834.1
Location: 1771230..1771640 (411 bp)
Type: Others
Protein ID: WP_103112835.1
Location: 1771760..1772167 (408 bp)
Type: Others
Protein ID: WP_002798105.1
Location: 1773279..1773533 (255 bp)
Type: Others
Protein ID: WP_103112836.1
Location: 1773517..1773789 (273 bp)
Type: Others
Protein ID: WP_016516511.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
D3800_RS085201765277..1766659-1383WP_103112833.1flavin monoamine oxidase family protein-
D3800_RS085251766769..1767617+849WP_002738738.1M28 family peptidase-
D3800_RS085301767843..1768217+375Protein_1692nucleotidyltransferase domain-containing protein-
D3800_RS085351768214..1768696+483WP_002738740.1hypothetical protein-
D3800_RS085401768848..1769342-495WP_002778801.1GNAT family N-acetyltransferaseToxin
D3800_RS085451769339..1769629-291WP_002778803.1DUF1778 domain-containing proteinAntitoxin
D3800_RS085501769894..1770166-273WP_002799473.1hypothetical protein-
D3800_RS085551770144..1770431-288Protein_1697BrnT family toxin-
D3800_RS085601770659..1771156-498WP_103112834.1hypothetical protein-
D3800_RS085651771230..1771640-411WP_103112835.1hypothetical protein-
D3800_RS085701771760..1772167-408WP_002798105.1hypothetical protein-
D3800_RS085751772652..1772978+327WP_202861585.1DUF4258 domain-containing protein-
D3800_RS085801772975..1773190+216WP_002757627.1hypothetical protein-
D3800_RS085851773279..1773533-255WP_103112836.1BrnA antitoxin family protein-
D3800_RS085901773517..1773789-273WP_016516511.1BrnT family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--1773953..17751401187


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-142)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 17613.35 Da        Isoelectric Point: 8.0169

>T143480 WP_002778801.1 NZ_CP046058:c1769342-1768848 [Microcystis aeruginosa NIES-298]
MNLTPPEPLASYHSITDFSCGITSLDDCLKRRAYANQASGATRTFVTCVDNRVVGYYALASGAISIQSANGKFRRNMPNP
IPVVILARLAVDTSYQGQGLGCGLFRDGALRVVKAADTIGIRGIIVHAISEEAKNFYLALGFDVSPLEPMTLMITLNDLR
ACIA

Download         Length: 495 bp

>T143480 NZ_CP046058:c1769342-1768848 [Microcystis aeruginosa NIES-298]
ATGAATTTGACACCACCTGAACCTCTGGCTAGTTATCACTCAATCACTGATTTTTCCTGCGGAATTACTTCTCTTGATGA
TTGCTTGAAGCGTCGAGCTTATGCTAATCAAGCCAGTGGTGCAACTAGAACTTTTGTTACCTGCGTTGACAATAGGGTAG
TTGGGTATTACGCCCTTGCTTCCGGGGCGATTAGTATACAATCAGCTAATGGTAAATTTCGGCGGAATATGCCTAACCCA
ATTCCAGTGGTAATTTTGGCACGATTGGCAGTAGATACTTCTTACCAAGGTCAAGGTTTAGGATGCGGTTTATTTCGTGA
TGGTGCGCTACGGGTTGTTAAAGCGGCTGATACCATTGGTATTCGGGGAATTATTGTTCATGCTATTTCAGAAGAAGCTA
AGAATTTTTATTTGGCTTTAGGTTTTGATGTGTCTCCTCTTGAACCGATGACGTTGATGATTACTCTTAATGATTTACGC
GCTTGTATTGCTTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11041.66 Da        Isoelectric Point: 9.7643

>AT143480 WP_002778803.1 NZ_CP046058:c1769629-1769339 [Microcystis aeruginosa NIES-298]
MSSKTKSKTPRNTLNLRIKPEERNLIDMAAKVQGKNRTDFILEAARNAAEETLLERTIFWASPEAYAEFIALLDAPPQPN
ERLRKTMQTLAPWEKE

Download         Length: 291 bp

>AT143480 NZ_CP046058:c1769629-1769339 [Microcystis aeruginosa NIES-298]
ATGAGTAGTAAAACAAAAAGTAAGACTCCGCGTAATACCCTAAATTTGCGAATTAAGCCAGAAGAACGCAATTTGATCGA
TATGGCAGCCAAAGTGCAAGGTAAGAATAGAACTGATTTTATTTTGGAAGCCGCGCGGAATGCTGCGGAGGAAACTTTGC
TCGAACGTACTATTTTTTGGGCTAGTCCAGAGGCTTATGCAGAATTTATCGCACTTCTAGATGCACCACCTCAACCTAAT
GAACGTTTACGCAAAACCATGCAGACGCTCGCACCTTGGGAGAAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBI4GLQ9

Antitoxin

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Source
ID
Structure
AlphaFold DBI4GLR0

References