Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 3897128..3897779 Replicon chromosome
Accession NZ_CP046057
Organism Bacillus sp. N3536

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag GI482_RS19360 Protein ID WP_144539613.1
Coordinates 3897429..3897779 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag GI482_RS19355 Protein ID WP_144539611.1
Coordinates 3897128..3897424 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GI482_RS19330 3892159..3893658 + 1500 WP_154312216.1 PH domain-containing protein -
GI482_RS19335 3893703..3894332 - 630 WP_144539603.1 rhomboid family intramembrane serine protease -
GI482_RS19340 3894401..3894754 + 354 WP_144539605.1 holo-ACP synthase -
GI482_RS19345 3894853..3895833 + 981 WP_186318211.1 outer-membrane lipoprotein carrier protein LolA -
GI482_RS19350 3895903..3897012 + 1110 WP_144539609.1 alanine racemase -
GI482_RS19355 3897128..3897424 + 297 WP_144539611.1 transcriptional regulator Antitoxin
GI482_RS19360 3897429..3897779 + 351 WP_144539613.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GI482_RS19365 3898080..3898907 + 828 WP_151112498.1 STAS domain-containing protein -
GI482_RS19370 3898907..3899269 + 363 WP_144539618.1 STAS domain-containing protein -
GI482_RS19375 3899276..3899677 + 402 WP_144539620.1 anti-sigma regulatory factor -
GI482_RS19380 3899690..3900691 + 1002 WP_144539622.1 PP2C family protein-serine/threonine phosphatase -
GI482_RS19385 3900761..3901102 + 342 WP_144539624.1 STAS domain-containing protein -
GI482_RS19390 3901089..3901559 + 471 WP_144539626.1 anti-sigma B factor RsbW -
GI482_RS19395 3901537..3902319 + 783 WP_144539628.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12885.82 Da        Isoelectric Point: 4.8943

>T143472 WP_144539613.1 NZ_CP046057:3897429-3897779 [Bacillus sp. N3536]
MIVKRGDVFFADLSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKEYDFERDSVILLEQL
RTIDKSRLTDKITHLDEDVMEEVDHALGISLGIVKF

Download         Length: 351 bp

>T143472 NZ_CP061108:907461-907868 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10961.68 Da        Isoelectric Point: 6.8617

>AT143472 WP_144539611.1 NZ_CP046057:3897128-3897424 [Bacillus sp. N3536]
MSEVFAVVSDKKKKEALIEIPMQMVSEGVQTSKSLTGRESVARVHANEYMKKGQANLIREAMMKGYVEMSHINLSICMEC
LHAEYEAQHTTERLVSGG

Download         Length: 297 bp

>AT143472 NZ_CP061108:907214-907480 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References