Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 2446894..2447396 Replicon chromosome
Accession NZ_CP046056
Organism Venatoribacter cucullus strain ASxL5

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag GJQ55_RS11620 Protein ID WP_228345127.1
Coordinates 2446894..2447148 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GJQ55_RS11625 Protein ID WP_228345128.1
Coordinates 2447145..2447396 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJQ55_RS11590 (GJQ55_11520) 2443299..2443967 + 669 WP_228345121.1 metallophosphoesterase -
GJQ55_RS11595 (GJQ55_11525) 2443954..2444928 - 975 WP_228345122.1 RluA family pseudouridine synthase -
GJQ55_RS11600 (GJQ55_11530) 2445341..2445631 + 291 WP_228345123.1 DUF1330 domain-containing protein -
GJQ55_RS11605 (GJQ55_11535) 2445728..2446126 + 399 WP_228345124.1 GFA family protein -
GJQ55_RS11610 (GJQ55_11540) 2446193..2446465 + 273 WP_228345125.1 hypothetical protein -
GJQ55_RS11615 (GJQ55_11545) 2446607..2446822 + 216 WP_228345126.1 TIGR02450 family Trp-rich protein -
GJQ55_RS11620 (GJQ55_11550) 2446894..2447148 - 255 WP_228345127.1 Txe/YoeB family addiction module toxin Toxin
GJQ55_RS11625 (GJQ55_11555) 2447145..2447396 - 252 WP_228345128.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GJQ55_RS11630 (GJQ55_11560) 2447606..2449234 + 1629 WP_228345129.1 NAD(P)/FAD-dependent oxidoreductase -
GJQ55_RS11635 (GJQ55_11565) 2449231..2449980 + 750 WP_228345130.1 RNA methyltransferase -
GJQ55_RS11640 (GJQ55_11570) 2450008..2450790 - 783 WP_228345131.1 FAD-binding oxidoreductase -
GJQ55_RS11645 (GJQ55_11575) 2451009..2451917 + 909 WP_228345132.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10271.75 Da        Isoelectric Point: 9.2909

>T143471 WP_228345127.1 NZ_CP046056:c2447148-2446894 [Venatoribacter cucullus]
MKLIFSEHAWEDYLYWQKTDKRTLNRINSLIKETLRNPFEGIGKPEPLKHNLTGYWSRRINEEDRMVYKVTDDALLIAQL
RYHY

Download         Length: 255 bp

>T143471 NZ_CP061108:758569-758865 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9213.45 Da        Isoelectric Point: 4.7513

>AT143471 WP_228345128.1 NZ_CP046056:c2447396-2447145 [Venatoribacter cucullus]
MDAISYTSARSNLAQMMQQVCDDHSPVIITRNKAPSVVMLSLEDYEALQETAYLLRAPKNARRLLASVAELESGKGTERE
LSE

Download         Length: 252 bp

>AT143471 NZ_CP061108:758867-759262 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References