Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1692999..1693579 Replicon chromosome
Accession NZ_CP046056
Organism Venatoribacter cucullus strain ASxL5

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GJQ55_RS08005 Protein ID WP_228344459.1
Coordinates 1692999..1693301 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GJQ55_RS08010 Protein ID WP_228344460.1
Coordinates 1693298..1693579 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJQ55_RS07985 (GJQ55_07925) 1688261..1688701 + 441 WP_228344455.1 DNA polymerase III subunit chi -
GJQ55_RS07990 (GJQ55_07930) 1688701..1689372 + 672 WP_228344456.1 hypothetical protein -
GJQ55_RS07995 (GJQ55_07935) 1689479..1692421 + 2943 WP_228344457.1 valine--tRNA ligase -
GJQ55_RS08000 (GJQ55_07940) 1692525..1692773 - 249 WP_228344458.1 DUF3297 family protein -
GJQ55_RS08005 (GJQ55_07945) 1692999..1693301 - 303 WP_228344459.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJQ55_RS08010 (GJQ55_07950) 1693298..1693579 - 282 WP_228344460.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GJQ55_RS08015 (GJQ55_07955) 1693742..1694002 - 261 WP_228344461.1 DUF4282 domain-containing protein -
GJQ55_RS08020 (GJQ55_07960) 1694089..1694889 - 801 WP_086994183.1 class III extradiol ring-cleavage dioxygenase -
GJQ55_RS08025 (GJQ55_07965) 1694985..1695446 - 462 WP_228344462.1 isoprenylcysteine carboxylmethyltransferase family protein -
GJQ55_RS08030 (GJQ55_07970) 1695543..1695848 - 306 WP_125867756.1 chorismate mutase -
GJQ55_RS08035 (GJQ55_07975) 1695943..1696404 - 462 WP_228344462.1 isoprenylcysteine carboxylmethyltransferase family protein -
GJQ55_RS08040 (GJQ55_07980) 1696528..1696848 - 321 WP_228344463.1 hypothetical protein -
GJQ55_RS08045 (GJQ55_07985) 1696923..1697663 - 741 WP_228344464.1 hypothetical protein -
GJQ55_RS08050 (GJQ55_07990) 1697653..1698477 - 825 WP_228344465.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1692525..1709134 16609


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-74)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11426.94 Da        Isoelectric Point: 4.2597

>T143470 WP_228344459.1 NZ_CP046056:c1693301-1692999 [Venatoribacter cucullus]
MKVVWSPLALERVEDTALYIAEDNPDAAVRWVEDLFTTVEHLADFPESGRMVPEVGSPRIRELIFGTYRVIYSAKDQVDI
LTVRRSSQLLRMSELGDDET

Download         Length: 303 bp

>T143470 NZ_CP061108:c645494-645030 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10732.22 Da        Isoelectric Point: 6.2387

>AT143470 WP_228344460.1 NZ_CP046056:c1693579-1693298 [Venatoribacter cucullus]
MSRVRVDEDIRPLSEFRAAVATFVRQIHETRRPMVLTQRGRGVAVLVDVHEYERMQERLEILEEVYKAEEQIASGEGVAH
EDAKTRILSSLAR

Download         Length: 282 bp

>AT143470 NZ_CP061108:c645829-645494 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References