Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1208817..1209379 Replicon chromosome
Accession NZ_CP046056
Organism Venatoribacter cucullus strain ASxL5

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GJQ55_RS05785 Protein ID WP_228346565.1
Coordinates 1208817..1209098 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GJQ55_RS05790 Protein ID WP_228346566.1
Coordinates 1209095..1209379 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJQ55_RS05755 (GJQ55_05705) 1203889..1204536 - 648 WP_228346559.1 lytic transglycosylase domain-containing protein -
GJQ55_RS05760 (GJQ55_05710) 1204530..1206266 - 1737 WP_228346560.1 proline--tRNA ligase -
GJQ55_RS05765 (GJQ55_05715) 1206477..1207130 + 654 WP_228346561.1 DUF938 domain-containing protein -
GJQ55_RS05770 (GJQ55_05720) 1207130..1207702 + 573 WP_228346562.1 DNA-3-methyladenine glycosylase I -
GJQ55_RS05775 (GJQ55_05725) 1207741..1208448 + 708 WP_228346563.1 SIMPL domain-containing protein -
GJQ55_RS05780 (GJQ55_05730) 1208486..1208788 + 303 WP_228346564.1 phage terminase large subunit family protein -
GJQ55_RS05785 (GJQ55_05735) 1208817..1209098 - 282 WP_228346565.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJQ55_RS05790 (GJQ55_05740) 1209095..1209379 - 285 WP_228346566.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GJQ55_RS05795 (GJQ55_05745) 1209484..1210311 - 828 WP_228346567.1 uroporphyrinogen-III C-methyltransferase -
GJQ55_RS05800 (GJQ55_05750) 1210308..1212980 - 2673 WP_228346758.1 nitrate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(1-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-75)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10834.60 Da        Isoelectric Point: 5.0893

>T143468 WP_228346565.1 NZ_CP046056:c1209098-1208817 [Venatoribacter cucullus]
MIAWEEESLNDREKIFEYLYQFNPIAAEKTDDLIVAKVETLIAQPLMGVERVGIRGRLLIIPDVSLMVVYFFDGSTIRIL
RVLHQKQQYPHSN

Download         Length: 282 bp

>T143468 NZ_CP061104:c37714-37433 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10769.17 Da        Isoelectric Point: 7.1689

>AT143468 WP_228346566.1 NZ_CP046056:c1209379-1209095 [Venatoribacter cucullus]
METRIQFRIAEDTKRLAQQLAESQGRTLSDACRELAEQMAEQQRKVLSHDAWLTEQVTQAFAKLDSGQAVFVEHNAAQAA
MEERKAIIRKRLNQ

Download         Length: 285 bp

>AT143468 NZ_CP061104:c37955-37704 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References