Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 551615..552137 Replicon chromosome
Accession NZ_CP046052
Organism Methylocystis heyeri strain H2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag H2LOC_RS02380 Protein ID WP_136494921.1
Coordinates 551862..552137 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag H2LOC_RS02375 Protein ID WP_136494920.1
Coordinates 551615..551875 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2LOC_RS02355 548078..548314 + 237 WP_136494918.1 phosphate starvation-inducible protein PsiF -
H2LOC_RS02360 548466..549716 - 1251 WP_154331548.1 FAD-binding oxidoreductase -
H2LOC_RS02365 549919..551061 + 1143 WP_136494919.1 DNA cytosine methyltransferase -
H2LOC_RS02370 551058..551462 + 405 WP_154331549.1 DNA mismatch endonuclease Vsr -
H2LOC_RS02375 551615..551875 + 261 WP_136494920.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H2LOC_RS02380 551862..552137 + 276 WP_136494921.1 type II toxin-antitoxin system YafQ family toxin Toxin
H2LOC_RS02385 552251..552820 - 570 WP_136494922.1 elongation factor P -
H2LOC_RS02390 552959..554005 + 1047 WP_136494923.1 EF-P lysine aminoacylase GenX -
H2LOC_RS02395 554007..554678 + 672 WP_202620515.1 SDR family oxidoreductase -
H2LOC_RS02400 554679..555734 + 1056 WP_136494924.1 lysine-2,3-aminomutase-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-78)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10699.31 Da        Isoelectric Point: 6.7181

>T143466 WP_136494921.1 NZ_CP046052:551862-552137 [Methylocystis heyeri]
MQEIRYTSRFKLSAGTIWSFAKKIDKLLMDAVSLLAVDEALPRSYFDHELTGEWKDFRDCHLRPDLILIYRKPDDNRLEL
VRLGSHSEIGF

Download         Length: 276 bp

>T143466 NZ_CP061103:c37958-37578 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACGGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGTATACAGGTATATGATTCTCCCGTGCTGGTGGAACTTGCGGTGGGGGCCGCAACTGG
TGAAATCCCCGTATCTTCAGTAGCGGAAAAACTACGTGAATTATTTGGTTCCAATATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9112.61 Da        Isoelectric Point: 6.2996

>AT143466 WP_136494920.1 NZ_CP046052:551615-551875 [Methylocystis heyeri]
MTNTTVRARIDEQVKEEAAAVLASIGLTVSDAFRLMMMRIAKDKALPFEPLVPNAETVEAMKAARQGALAKAGTPDKLLA
SLNAGD

Download         Length: 261 bp

>AT143466 NZ_CP061103:c38179-37958 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGAGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTTGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References