Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 731369..732018 Replicon chromosome
Accession NZ_CP046049
Organism Proteus mirabilis strain DY.F1.2

Toxin (Protein)


Gene name vagD Uniprot ID B4EZB9
Locus tag GJR68_RS03525 Protein ID WP_012368534.1
Coordinates 731599..732018 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B4EZC0
Locus tag GJR68_RS03520 Protein ID WP_012368535.1
Coordinates 731369..731602 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJR68_RS03495 727079..727558 - 480 WP_060555753.1 Hcp family type VI secretion system effector -
GJR68_RS03500 728008..728295 - 288 WP_104731871.1 transposase -
GJR68_RS03505 728343..728564 + 222 WP_060555751.1 hypothetical protein -
GJR68_RS03510 728781..729989 - 1209 WP_060555750.1 DUF262 domain-containing protein -
GJR68_RS03515 730950..731102 - 153 WP_172764486.1 hypothetical protein -
GJR68_RS03520 731369..731602 + 234 WP_012368535.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GJR68_RS03525 731599..732018 + 420 WP_012368534.1 type II toxin-antitoxin system VapC family toxin Toxin
GJR68_RS03530 732243..732566 + 324 WP_104731870.1 hypothetical protein -
GJR68_RS03535 732544..732960 + 417 WP_046334846.1 hypothetical protein -
GJR68_RS03540 733612..734229 + 618 WP_004246809.1 glucose-1-phosphatase -
GJR68_RS03545 734310..734747 + 438 WP_004246810.1 D-tyrosyl-tRNA(Tyr) deacylase -
GJR68_RS03550 734771..735685 + 915 WP_004249085.1 fatty acid biosynthesis protein FabY -
GJR68_RS03555 735861..736739 + 879 WP_017628653.1 23S rRNA pseudouridine(2604) synthase RluF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(9-56)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15371.88 Da        Isoelectric Point: 7.7288

>T143463 WP_012368534.1 NZ_CP046049:731599-732018 [Proteus mirabilis]
VKKVYMLDTNICSFIMREQPISLLEKLQKCVMNHDTIVISAITYSEMRFGAIGKKASPKHNRLVDAFCERVDAILAWDKA
AVDATTVIKKCLSDVGLPIGNNDSAIAGHAVAVNAILVTNNTREFSRVEGLKIEDWTHV

Download         Length: 420 bp

>T143463 NZ_CP061102:c51421-51215 [Escherichia coli]
ATGAAGTACCTTAACACTACTGATTGTAGCCTCTTCCTTGCAGAGAGGTCAAAGTTTATGACGAAATATGCCCTTATCGG
GTTGCTCGCCGTGTGCGCTACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAGCTGAATATTCACAGGG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8890.06 Da        Isoelectric Point: 4.4870

>AT143463 WP_012368535.1 NZ_CP046049:731369-731602 [Proteus mirabilis]
MRTRTVAVFKNGSNRAIRLPKDFDFDGVNELEISRDGDCIILRPVKPNWISLQNEEKADSDFLLERDDVIEEGRVIL

Download         Length: 234 bp

>AT143463 NZ_CP061102:51408-51469 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZB9

Antitoxin

Source ID Structure
AlphaFold DB B4EZC0

References