Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4127741..4128542 Replicon chromosome
Accession NZ_CP046048
Organism Proteus mirabilis strain HN2p

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag GJR66_RS19085 Protein ID WP_001094437.1
Coordinates 4127741..4128118 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0XTQ1
Locus tag GJR66_RS19090 Protein ID WP_001390338.1
Coordinates 4128165..4128542 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJR66_RS19050 4122934..4123617 - 684 WP_004246670.1 hypothetical protein -
GJR66_RS19055 4123707..4124330 - 624 WP_004246669.1 common pilus major fimbrillin subunit EcpA -
GJR66_RS19060 4124470..4124790 - 321 WP_004246668.1 helix-turn-helix transcriptional regulator -
GJR66_RS19065 4125605..4125796 - 192 Protein_3702 virulence RhuM family protein -
GJR66_RS19070 4126109..4126954 - 846 WP_001274561.1 DUF4942 domain-containing protein -
GJR66_RS19075 4127039..4127326 - 288 WP_060589331.1 DUF957 domain-containing protein -
GJR66_RS19080 4127256..4127744 - 489 WP_000761716.1 hypothetical protein -
GJR66_RS19085 4127741..4128118 - 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
GJR66_RS19090 4128165..4128542 - 378 WP_001390338.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GJR66_RS19095 4128705..4128926 - 222 WP_000692345.1 DUF987 domain-containing protein -
GJR66_RS19100 4128989..4129465 - 477 WP_001535682.1 RadC family protein -
GJR66_RS19105 4129481..4129954 - 474 WP_000855064.1 antirestriction protein -
GJR66_RS19110 4130296..4131114 - 819 WP_001535681.1 DUF945 domain-containing protein -
GJR66_RS19115 4131269..4131427 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T143461 WP_001094437.1 NZ_CP046048:c4128118-4127741 [Proteus mirabilis]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T143461 NZ_CP061101:c4535916-4535605 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13745.44 Da        Isoelectric Point: 5.0463

>AT143461 WP_001390338.1 NZ_CP046048:c4128542-4128165 [Proteus mirabilis]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT143461 NZ_CP061101:c4535604-4535314 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XTQ1

References