Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3575345..3577067 Replicon chromosome
Accession NZ_CP046048
Organism Proteus mirabilis strain HN2p

Toxin (Protein)


Gene name mosT Uniprot ID D0FZT9
Locus tag GJR66_RS16580 Protein ID WP_000356587.1
Coordinates 3575345..3576283 (-) Length 313 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A1U9VYW4
Locus tag GJR66_RS16585 Protein ID WP_000095578.1
Coordinates 3576276..3577067 (-) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJR66_RS16560 3571286..3571798 - 513 WP_024008829.1 S26 family signal peptidase -
GJR66_RS16565 3571782..3572129 - 348 WP_024008830.1 hypothetical protein -
GJR66_RS16570 3572122..3574521 - 2400 WP_024008831.1 type IV secretion system protein TraC -
GJR66_RS16575 3574521..3575213 - 693 WP_024008832.1 DsbC family protein -
GJR66_RS16580 3575345..3576283 - 939 WP_000356587.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
GJR66_RS16585 3576276..3577067 - 792 WP_000095578.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
GJR66_RS16590 3577288..3577674 - 387 WP_000180225.1 hypothetical protein -
GJR66_RS16595 3577671..3578243 - 573 WP_024008834.1 type IV conjugative transfer system lipoprotein TraV -
GJR66_RS16600 3578318..3579607 - 1290 WP_049195464.1 TraB/VirB10 family protein -
GJR66_RS16605 3579610..3580506 - 897 WP_032194332.1 type-F conjugative transfer system secretin TraK -
GJR66_RS16610 3580490..3581116 - 627 WP_000667167.1 hypothetical protein -
GJR66_RS16615 3581113..3581394 - 282 WP_000433891.1 type IV conjugative transfer system protein TraL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(J) / blaCMY-2 - 3483515..3670314 186799


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(99-250)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35548.82 Da        Isoelectric Point: 4.9081

>T143457 WP_000356587.1 NZ_CP046048:c3576283-3575345 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Download         Length: 939 bp

>T143457 NZ_CP061101:3718265-3718543 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAACGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 30095.47 Da        Isoelectric Point: 9.5097

>AT143457 WP_000095578.1 NZ_CP046048:c3577067-3576276 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRVDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Download         Length: 792 bp

>AT143457 NZ_CP061101:3718002-3718262 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9VZ44

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9VYW4

References