Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 239021..239622 Replicon chromosome
Accession NZ_CP046048
Organism Proteus mirabilis strain HN2p

Toxin (Protein)


Gene name doc Uniprot ID A0A2X2BIG8
Locus tag GJR66_RS01130 Protein ID WP_004246497.1
Coordinates 239021..239404 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag GJR66_RS01135 Protein ID WP_004246496.1
Coordinates 239401..239622 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJR66_RS01105 234392..234850 + 459 WP_017628716.1 GNAT family N-acetyltransferase -
GJR66_RS01110 234946..235683 - 738 WP_004249950.1 sel1 repeat family protein -
GJR66_RS01115 235792..236691 + 900 WP_017628715.1 N-acetylmuramic acid 6-phosphate etherase -
GJR66_RS01120 237048..238286 - 1239 WP_017628714.1 HipA domain-containing protein -
GJR66_RS01125 238299..238613 - 315 WP_004246498.1 helix-turn-helix domain-containing protein -
GJR66_RS01130 239021..239404 - 384 WP_004246497.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GJR66_RS01135 239401..239622 - 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GJR66_RS01140 239867..240730 - 864 WP_004249947.1 YicC family protein -
GJR66_RS01145 240857..241573 + 717 WP_004249760.1 ribonuclease PH -
GJR66_RS01150 241655..242299 + 645 WP_017628713.1 orotate phosphoribosyltransferase -
GJR66_RS01155 242618..243223 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
GJR66_RS01160 243343..243801 - 459 WP_004246490.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14471.53 Da        Isoelectric Point: 8.5125

>T143455 WP_004246497.1 NZ_CP046048:c239404-239021 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T143455 NZ_CP061101:3512853-3513071 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT143455 WP_004246496.1 NZ_CP046048:c239622-239401 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT143455 NZ_CP061101:3512453-3512827 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2BIG8

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References