Detailed information of TA system TA143454

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 213631..215202
• Replicon: chromosome
• Accession: NZ_CP046048
• Organism: Proteus mirabilis strain HN2p

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: B4F0T8
• Locus tag: GJR66_RS01010
• Protein ID: WP_012368637.1
• Coordinates: 213631..214944 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: GJR66_RS01015
• Protein ID: WP_004249771.1
• Coordinates: 214945..215202 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJR66_RS00990	208800..209603	+	804	WP_004249775.1	energy transducer TonB	-
GJR66_RS00995	209657..211618	-	1962	WP_012368635.1	hypothetical protein	-
GJR66_RS01000	211650..212579	-	930	WP_004246518.1	metallophosphoesterase	-
GJR66_RS01005	212764..213228	-	465	WP_004249773.1	DUF1097 domain-containing protein	-
GJR66_RS01010	213631..214944	-	1314	WP_012368637.1	type II toxin-antitoxin system HipA family toxin	Toxin
GJR66_RS01015	214945..215202	-	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
GJR66_RS01020	215351..216715	-	1365	WP_004246513.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
GJR66_RS01025	216853..218493	-	1641	WP_004246512.1	membrane protein insertase YidC	-
GJR66_RS01030	218496..218756	-	261	WP_012368639.1	membrane protein insertion efficiency factor YidD	-
GJR66_RS01035	218720..219079	-	360	WP_004246510.1	ribonuclease P protein component	-
GJR66_RS01040	219097..219240	-	144	WP_004246509.1	50S ribosomal protein L34	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49670.78 Da
• Isoelectric Point: 6.5023

>T143454 WP_012368637.1 NZ_CP046048:c214944-213631 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T143454 NZ_CP061101:2720147-2720254 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT143454 WP_004249771.1 NZ_CP046048:c215202-214945 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT143454 NZ_CP061101:c2720097-2720034 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: B4F0T8

Antitoxin

• AlphaFold DB: B4F0T9