Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2192839..2193488 Replicon chromosome
Accession NZ_CP046045
Organism Acinetobacter towneri strain 19110F47

Toxin (Protein)


Gene name vapC Uniprot ID N9B9L0
Locus tag GJD93_RS11670 Protein ID WP_004972405.1
Coordinates 2192839..2193258 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID N9CPX4
Locus tag GJD93_RS11675 Protein ID WP_004972406.1
Coordinates 2193258..2193488 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJD93_RS11640 2188165..2189097 - 933 WP_154321004.1 DUF4041 domain-containing protein -
GJD93_RS11645 2189379..2190044 - 666 WP_154321005.1 RluA family pseudouridine synthase -
GJD93_RS11650 2190238..2190951 - 714 WP_004972399.1 SIMPL domain-containing protein -
GJD93_RS11655 2191071..2191322 - 252 WP_154321006.1 hypothetical protein -
GJD93_RS11660 2191886..2192458 - 573 WP_096901555.1 DUF4126 domain-containing protein -
GJD93_RS11665 2192565..2192708 - 144 WP_004972403.1 zinc ribbon-containing protein -
GJD93_RS11670 2192839..2193258 - 420 WP_004972405.1 type II toxin-antitoxin system VapC family toxin Toxin
GJD93_RS11675 2193258..2193488 - 231 WP_004972406.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GJD93_RS11680 2193785..2196391 - 2607 WP_154321007.1 Fe/S-dependent 2-methylisocitrate dehydratase AcnD -
GJD93_RS11685 2196648..2197370 + 723 WP_154321008.1 folate-binding Fe/S cluster repair protein -
GJD93_RS11690 2197427..2197882 - 456 WP_070153729.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-128)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16147.60 Da        Isoelectric Point: 7.1858

>T143453 WP_004972405.1 NZ_CP046045:c2193258-2192839 [Acinetobacter towneri]
MQVQYLLDTNICIYIIKYRPEIVRQHFEKHLPHRNILISVITLGELRFGAEKSQHKEKALKVIDELTSMIQVVELDENVA
HHYAEIRQNLASKGQIIGANDLWLAAHARANHWVMVTNNEKEFTRVDGLKVENWVSNPL

Download         Length: 420 bp

>T143453 NZ_CP061101:2719612-2719719 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9068.42 Da        Isoelectric Point: 5.1972

>AT143453 WP_004972406.1 NZ_CP046045:c2193488-2193258 [Acinetobacter towneri]
MTTAKVFMTGRSQAIRLPKEFRFEGKEVEIFRRGDEVILREKPVTVDRLFKALSQMPNDFYADEREDLPPQEREMF

Download         Length: 231 bp

>AT143453 NZ_CP061101:c2719559-2719498 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N9B9L0

Antitoxin

Source ID Structure
AlphaFold DB N9CPX4

References