Detailed information of TA system TA143451

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1477714..1478288
• Replicon: chromosome
• Accession: NZ_CP046045
• Organism: Acinetobacter towneri strain 19110F47

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: N9B925
• Locus tag: GJD93_RS08150
• Protein ID: WP_004973562.1
• Coordinates: 1477714..1477902 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9B7X5
• Locus tag: GJD93_RS08155
• Protein ID: WP_004973564.1
• Coordinates: 1477905..1478288 (+)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJD93_RS08115	1472945..1473433	+	489	WP_004973550.1	helix-turn-helix transcriptional regulator	-
GJD93_RS08120	1473465..1473776	-	312	WP_026438386.1	TusE/DsrC/DsvC family sulfur relay protein	-
GJD93_RS08125	1473835..1474119	-	285	WP_154320741.1	hypothetical protein	-
GJD93_RS08130	1474185..1474535	-	351	WP_004973555.1	hypothetical protein	-
GJD93_RS08135	1474579..1474947	-	369	WP_154320742.1	sulfurtransferase complex subunit TusD	-
GJD93_RS08140	1475009..1476013	+	1005	WP_154320743.1	SDR family NAD(P)-dependent oxidoreductase	-
GJD93_RS08145	1476187..1477581	+	1395	WP_154320744.1	class II fumarate hydratase	-
GJD93_RS08150	1477714..1477902	+	189	WP_004973562.1	type II toxin-antitoxin system HicA family toxin	Toxin
GJD93_RS08155	1477905..1478288	+	384	WP_004973564.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GJD93_RS08160	1478664..1479155	+	492	WP_004973565.1	hypothetical protein	-
GJD93_RS08165	1479260..1480177	-	918	WP_104851971.1	LysR family transcriptional regulator	-
GJD93_RS08170	1480270..1481511	+	1242	WP_004973568.1	acyl-CoA dehydrogenase family protein	-
GJD93_RS08175	1481642..1482763	+	1122	WP_154320745.1	phosphotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7350.46 Da
• Isoelectric Point: 10.2954

>T143451 WP_004973562.1 NZ_CP046045:1477714-1477902 [Acinetobacter towneri]
MNSKDIIKRLEQEGWYKVGGKGDHEKYKHPEKPGHVVVPHPRKDMPIGTLRNIYKQAGWEWR

Nucleotide

• Length: 189 bp

>T143451 NZ_CP061101:2376529-2377851 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 14346.19 Da
• Isoelectric Point: 4.3695

>AT143451 WP_004973564.1 NZ_CP046045:1477905-1478288 [Acinetobacter towneri]
MLYPVYVHKDEDSAYGLTFPDFDGCFSAADEMQDIQRMAQEAVEVHFDGEDIPLPEPSSPEQWLGDERFEGGFWLLVDID
TTKVNTKSIRINISMPEALVKRIDAVAKKQHLSRSAFLAKSAEMALH

Nucleotide

• Length: 384 bp

>AT143451 NZ_CP061101:2376263-2376529 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: N9B925

Antitoxin

• AlphaFold DB: N9B7X5