Detailed information of TA system TA143449

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 937051..937579
• Replicon: chromosome
• Accession: NZ_CP046045
• Organism: Acinetobacter towneri strain 19110F47

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GJD93_RS05505
• Protein ID: WP_154320489.1
• Coordinates: 937051..937344 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: N9CRA2
• Locus tag: GJD93_RS05510
• Protein ID: WP_004970507.1
• Coordinates: 937334..937579 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJD93_RS05465	932402..932896	+	495	WP_004970523.1	flavin reductase	-
GJD93_RS05470	932968..933258	+	291	WP_019836372.1	type II toxin-antitoxin system HigB family toxin	-
GJD93_RS05475	933260..933661	+	402	WP_004970519.1	helix-turn-helix domain-containing protein	-
GJD93_RS05485	934002..934286	-	285	WP_004970518.1	cell division protein ZapA	-
GJD93_RS05490	934288..934839	-	552	WP_154320487.1	hypothetical protein	-
GJD93_RS05495	934904..935542	+	639	WP_004970514.1	UPF0149 family protein	-
GJD93_RS05500	935637..936971	+	1335	WP_154320488.1	Xaa-Pro aminopeptidase	-
GJD93_RS05505	937051..937344	-	294	WP_154320489.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GJD93_RS05510	937334..937579	-	246	WP_004970507.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GJD93_RS05515	937952..939160	+	1209	WP_154320490.1	2-octaprenyl-6-methoxyphenyl hydroxylase	-
GJD93_RS05520	939157..940407	+	1251	WP_154320491.1	FAD-dependent monooxygenase	-
GJD93_RS05525	940584..940832	+	249	WP_004972644.1	hypothetical protein	-
GJD93_RS05530	941024..941866	-	843	WP_131261744.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
GJD93_RS05535	942070..942498	+	429	WP_154320492.1	YraN family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-74)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11293.51 Da
• Isoelectric Point: 10.4456

>T143449 WP_154320489.1 NZ_CP046045:c937344-937051 [Acinetobacter towneri]
MTYKLLRHKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLKGDLAGCYKIKLLKAGVRLIYQVKDDQVVILLITVG
KRADNIVYDEAKKRIKD

Nucleotide

• Length: 294 bp

>T143449 NZ_CP061101:c1847075-1846698 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9238.59 Da
• Isoelectric Point: 4.2703

>AT143449 WP_004970507.1 NZ_CP046045:c937579-937334 [Acinetobacter towneri]
MATVNFRVDEALKEKSYSILKEQGISPTDFFTNILEYVATTGKLPVQKALLSEEDAELLALVRKRMNDPKEMFEEVTLDD
L

Nucleotide

• Length: 246 bp

>AT143449 NZ_CP061101:c1847533-1847165 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Structures

Antitoxin

• AlphaFold DB: N9CRA2