Detailed information of TA system TA143448

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 210244..210772
• Replicon: chromosome
• Accession: NZ_CP046045
• Organism: Acinetobacter towneri strain 19110F47

Toxin (Protein)

• Gene name: relE
• Uniprot ID: N8SCV7
• Locus tag: GJD93_RS02025
• Protein ID: WP_004733298.1
• Coordinates: 210244..210537 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1E8E1G7
• Locus tag: GJD93_RS02030
• Protein ID: WP_070154357.1
• Coordinates: 210527..210772 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJD93_RS01980	205578..205892	+	315	WP_070155405.1	hypothetical protein	-
GJD93_RS01985	205958..206251	-	294	WP_154320209.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GJD93_RS01990	206241..206486	-	246	WP_000246756.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
GJD93_RS01995	206654..207082	+	429	WP_004786455.1	organic hydroperoxide resistance protein	-
GJD93_RS02000	207089..207520	+	432	WP_154320210.1	MarR family transcriptional regulator	-
GJD93_RS02005	207651..207923	-	273	WP_154320211.1	helix-turn-helix domain-containing protein	-
GJD93_RS02010	207916..208227	-	312	WP_154320212.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GJD93_RS02015	208359..209684	-	1326	WP_154320213.1	ISNCY family transposase	-
GJD93_RS02020	209857..210156	-	300	WP_000358348.1	hypothetical protein	-
GJD93_RS02025	210244..210537	-	294	WP_004733298.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GJD93_RS02030	210527..210772	-	246	WP_070154357.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GJD93_RS02035	210942..211268	-	327	WP_004676063.1	hypothetical protein	-
GJD93_RS02040	211265..211687	-	423	WP_004676061.1	hypothetical protein	-
GJD93_RS02045	211791..212114	+	324	WP_004676058.1	hypothetical protein	-
GJD93_RS02050	212300..212977	+	678	WP_127801904.1	recombinase family protein	-
GJD93_RS02055	213121..214383	+	1263	WP_154320214.1	exodeoxyribonuclease VII large subunit	-
GJD93_RS02060	214376..214570	+	195	WP_004644823.1	exodeoxyribonuclease VII small subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11252.46 Da
• Isoelectric Point: 10.4456

>T143448 WP_004733298.1 NZ_CP046045:c210537-210244 [Acinetobacter towneri]
MTYKLLRHKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLKGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Nucleotide

• Length: 294 bp

>T143448 NZ_CP061101:1828967-1829221 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9204.56 Da
• Isoelectric Point: 4.2703

>AT143448 WP_070154357.1 NZ_CP046045:c210772-210527 [Acinetobacter towneri]
MATVNFRVDEALKEKSYSILKEQGIAPTEFFTNILEYIATTGKLPVQKALLSEEDADLLALVRKRVNDPKEMFEEVTLDD
L

Nucleotide

• Length: 246 bp

>AT143448 NZ_CP061101:1828719-1828970 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Structures

Toxin

• AlphaFold DB: N8SCV7

Antitoxin

• AlphaFold DB: A0A1E8E1G7