Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 205958..206486 | Replicon | chromosome |
| Accession | NZ_CP046045 | ||
| Organism | Acinetobacter towneri strain 19110F47 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | GJD93_RS01985 | Protein ID | WP_154320209.1 |
| Coordinates | 205958..206251 (-) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | N9B5Q7 |
| Locus tag | GJD93_RS01990 | Protein ID | WP_000246756.1 |
| Coordinates | 206241..206486 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GJD93_RS01940 | 201432..201863 | + | 432 | Protein_190 | ATP-binding protein | - |
| GJD93_RS01945 | 201921..202451 | + | 531 | WP_100219198.1 | recombinase family protein | - |
| GJD93_RS01950 | 202517..203320 | + | 804 | WP_001082319.1 | aminoglycoside O-phosphotransferase APH(3'')-Ib | - |
| GJD93_RS01955 | 203320..204156 | + | 837 | WP_000480968.1 | aminoglycoside O-phosphotransferase APH(6)-Id | - |
| GJD93_RS01965 | 204377..204734 | + | 358 | Protein_194 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GJD93_RS01970 | 204727..205029 | + | 303 | WP_001140620.1 | XRE family transcriptional regulator | - |
| GJD93_RS01975 | 205162..205575 | + | 414 | WP_070155403.1 | hypothetical protein | - |
| GJD93_RS01980 | 205578..205892 | + | 315 | WP_070155405.1 | hypothetical protein | - |
| GJD93_RS01985 | 205958..206251 | - | 294 | WP_154320209.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GJD93_RS01990 | 206241..206486 | - | 246 | WP_000246756.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| GJD93_RS01995 | 206654..207082 | + | 429 | WP_004786455.1 | organic hydroperoxide resistance protein | - |
| GJD93_RS02000 | 207089..207520 | + | 432 | WP_154320210.1 | MarR family transcriptional regulator | - |
| GJD93_RS02005 | 207651..207923 | - | 273 | WP_154320211.1 | helix-turn-helix domain-containing protein | - |
| GJD93_RS02010 | 207916..208227 | - | 312 | WP_154320212.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GJD93_RS02015 | 208359..209684 | - | 1326 | WP_154320213.1 | ISNCY family transposase | - |
| GJD93_RS02020 | 209857..210156 | - | 300 | WP_000358348.1 | hypothetical protein | - |
| GJD93_RS02025 | 210244..210537 | - | 294 | WP_004733298.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GJD93_RS02030 | 210527..210772 | - | 246 | WP_070154357.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| GJD93_RS02035 | 210942..211268 | - | 327 | WP_004676063.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | floR / tet(X4) / sul2 / aph(3'')-Ib / aph(6)-Id | - | 184462..209696 | 25234 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11354.64 Da Isoelectric Point: 10.5031
>T143446 WP_154320209.1 NZ_CP046045:c206251-205958 [Acinetobacter towneri]
MTYKLLRHKDFTAEWEKLPVAIREQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKY
MTYKLLRHKDFTAEWEKLPVAIREQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKY
Download Length: 294 bp
>T143446 NZ_CP061101:1357202-1357600 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAACATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTAACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA
ATGCTGAAATTCATGCTGGATACCAACATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTAACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9235.61 Da Isoelectric Point: 4.3142
>AT143446 WP_000246756.1 NZ_CP046045:c206486-206241 [Acinetobacter towneri]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L
Download Length: 246 bp
>AT143446 NZ_CP061101:1356975-1357202 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|