Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 117118..117702 Replicon plasmid p19110F47-2
Accession NZ_CP046044
Organism Acinetobacter towneri strain 19110F47

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag GJD93_RS00795 Protein ID WP_154320144.1
Coordinates 117400..117702 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag GJD93_RS00790 Protein ID WP_000985610.1
Coordinates 117118..117399 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJD93_RS00775 113955..115019 - 1065 WP_169538922.1 efflux RND transporter periplasmic adaptor subunit -
GJD93_RS00780 115545..116141 + 597 WP_074163998.1 LysE family transporter -
GJD93_RS00785 116169..116987 - 819 WP_032073151.1 AraC family transcriptional regulator -
GJD93_RS00790 117118..117399 - 282 WP_000985610.1 putative addiction module antidote protein Antitoxin
GJD93_RS00795 117400..117702 - 303 WP_154320144.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJD93_RS00800 117952..118161 + 210 WP_004976362.1 hypothetical protein -
GJD93_RS00805 118411..119865 + 1455 WP_026438532.1 SulP family inorganic anion transporter -
GJD93_RS00810 119976..120266 - 291 WP_004969304.1 putative addiction module antidote protein -
GJD93_RS00815 120268..120564 - 297 WP_004647749.1 type II toxin-antitoxin system RelE/ParE family toxin -
GJD93_RS00820 121000..122082 - 1083 WP_004969299.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(E) / msr(E) / erm(B) / blaOXA-58 / floR / tet(M) / aph(3')-Ia / aac(3)-IVa / aph(4)-Ia / sul2 - 1..143035 143035


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11558.10 Da        Isoelectric Point: 4.6838

>T143443 WP_154320144.1 NZ_CP046044:c117702-117400 [Acinetobacter towneri]
MYSIYTTEVFDDWFTKLKDLQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL

Download         Length: 303 bp

>T143443 NZ_CP061101:669102-669416 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGCTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10109.67 Da        Isoelectric Point: 8.0018

>AT143443 WP_000985610.1 NZ_CP046044:c117399-117118 [Acinetobacter towneri]
MAIKLRKWDSAEHLKTEEDMQAYLQACIDESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI

Download         Length: 282 bp

>AT143443 NZ_CP061101:669413-669829 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCAAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References