Detailed information of TA system TA143439

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 834372..834855
• Replicon: chromosome
• Accession: NZ_CP046041
• Organism: Streptococcus equi subsp. zooepidemicus strain AZ-45470

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GJS33_RS03970
• Protein ID: WP_154298876.1
• Coordinates: 834595..834855 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4U2B9
• Locus tag: GJS33_RS03965
• Protein ID: WP_012515410.1
• Coordinates: 834372..834593 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJS33_RS03940	830893..831174	+	282	WP_154298874.1	hypothetical protein	-
GJS33_RS03945	831357..831812	-	456	WP_043038876.1	DUF1694 domain-containing protein	-
GJS33_RS03950	832044..833351	+	1308	WP_012515409.1	phosphopyruvate hydratase	-
GJS33_RS03955	833590..833679	+	90	WP_111677961.1	type I toxin-antitoxin system Fst family toxin	-
GJS33_RS03960	833926..834162	-	237	Protein_749	transposase	-
GJS33_RS03965	834372..834593	+	222	WP_012515410.1	hypothetical protein	Antitoxin
GJS33_RS03970	834595..834855	+	261	WP_154298876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GJS33_RS03975	834935..835911	+	977	Protein_752	IS3 family transposase	-
GJS33_RS09815	835912..836166	+	255	Protein_753	HAD hydrolase-like protein	-
GJS33_RS03985	836636..839416	+	2781	WP_012515415.1	endonuclease/exonuclease/phosphatase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10305.84 Da
• Isoelectric Point: 9.8428

>T143439 WP_154298876.1 NZ_CP046041:834595-834855 [Streptococcus equi subsp. zooepidemicus]
MYRIEYSKKAQKQIKKVDKQIQRLLFAWIDKYLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKMVVLALEFG
HRRDVY

Nucleotide

• Length: 261 bp

>T143439 NZ_CP061093:92632-92919 [Roseomonas marmotae]
GTGAGGCTGGAATGGTCCGCCCTGGCGCTCGCCGACCGGGCGGCCATCTTCGACCATATCGCGGCGGAGAACCCCCGCGC
GGCCGTGGCGCTGGACCAGCAGCTGGCCGGCCGGATCGCCGCCCTGCCCGAATTTCCGCGGCGCGGGCGCCCGGGACGGG
TGGAGGCAACGCGCGAGCTGCCGCTGCCGCCCACGCCCTATATCGCCGTCTATCAGCTCCGGGGTGATACCCTCCGCATC
CTGCGCCTGCTGCACGGCGCCCGGCTCTGGCCCGATGAACGCTCCTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8536.57 Da
• Isoelectric Point: 4.6104

>AT143439 WP_012515410.1 NZ_CP046041:834372-834593 [Streptococcus equi subsp. zooepidemicus]
MSTVTIRLNQEEEIFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYAEYKADPETISHADFKKELGL

Nucleotide

• Length: 222 bp

>AT143439 NZ_CP061093:92336-92635 [Roseomonas marmotae]
ATGCCCGCCAATGCCCTGATCCAGACCCGCATCGACCCACAGGTGAAGGAACGCGCCGGCGCCGTGCTGGAGAAGATGGG
GCTGACCCTGTCGGATGCCGTGCGGATCCTGCTGACCCGCACCGCCAATGAGGGCGCCCTGCCCTTCGCCCTGCTGGCCG
ATCCCGCCCAGCACGATGCCTGGTTCCGCGCCAAGGTGCGCGAGGCTCTGGAAGACCCCCGCCCCGCCCTGCCGCAGGAG
GAGGCCGAGGCTCTCTTCGCGCGCCGCCGGGCGGAGGCGCTGCGCGGGCAGGATGGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A380KCN4