Detailed information of TA system TA143438

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1571985..1573231
• Replicon: chromosome
• Accession: NZ_CP046040
• Organism: Streptococcus equi subsp. zooepidemicus strain OH-71905

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A6D2LV21
• Locus tag: GJS32_RS07450
• Protein ID: WP_014623239.1
• Coordinates: 1571985..1572755 (-)
• Length: 257 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: GJS32_RS07455
• Protein ID: WP_014623240.1
• Coordinates: 1572755..1573231 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJS32_RS07430	1567061..1567252	-	192	WP_014623235.1	hypothetical protein	-
GJS32_RS07435	1567382..1570027	-	2646	WP_014623236.1	AAA family ATPase	-
GJS32_RS07440	1570032..1570718	-	687	WP_014623237.1	hypothetical protein	-
GJS32_RS07445	1570711..1571982	-	1272	WP_038674121.1	hypothetical protein	-
GJS32_RS07450	1571985..1572755	-	771	WP_014623239.1	zeta toxin family protein	Toxin
GJS32_RS07455	1572755..1573231	-	477	WP_014623240.1	helix-turn-helix domain-containing protein	Antitoxin
GJS32_RS07460	1573301..1573588	-	288	WP_038674119.1	hypothetical protein	-
GJS32_RS07465	1573633..1574028	-	396	WP_014623241.1	hypothetical protein	-
GJS32_RS07470	1574032..1574259	-	228	WP_000110926.1	hypothetical protein	-
GJS32_RS07475	1574313..1575399	-	1087	Protein_1453	toprim domain-containing protein	-
GJS32_RS07480	1575438..1576076	-	639	WP_014623243.1	hypothetical protein	-
GJS32_RS07485	1576259..1577773	-	1515	WP_038674112.1	ABC transporter ATP-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1561119..1576076	14957

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 257 a.a.
• Molecular weight: 29112.91 Da
• Isoelectric Point: 5.8794

>T143438 WP_014623239.1 NZ_CP046040:c1572755-1571985 [Streptococcus equi subsp. zooepidemicus]
MRLEEFSQDDFDLALKRTIRSLTRGKTTSVSPKAILLGGQSGAGKTTIHRIEQKEFQGNIIIIDGDSYRSLHPNYLALHE
EYGKDSVDYTKGFAGKMVEHLVDELSKQGYHLLIEGTLRTTEVPRKTARLLNSRGYQVSLALIATKPELSYLSTLIRYEE
VYAVNPNQARATPKEHHDGIVDHLVDNLRELENDKLFGQIQIYQRDRTCVYDSKTDEGSAADVLQECLFGKWSKVEEEML
KVGQECLRELEFKGEC

Nucleotide

• Length: 771 bp

>T143438 NZ_CP061089:610593-610874 [Brucella sp. 6810]
ATGATCCGATCTTACAAGAACAGCGTCACTGAAACCGTGGCGTGGGGTAAAGCTCCAAAAGGGTTCCCATCTGATCTTGT
CCGGGTATCAGTTCGTAAGCTCACCATGCTCGACAACGCAGTAACCCTTGATGATCTTCGCTCCCCACCGGGAAATCGGC
TTGAAGCTCTCAAGGGCGACCGCCAAGGTCAGCATTCAATCCGCATAAACGACCAGTGGCGCATCTGCTTTGTCTGGACA
GATGCTGGCGCTGAACAGGTTGAAATCGTAGATTATCACTGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18032.39 Da
• Isoelectric Point: 4.3193

>AT143438 WP_014623240.1 NZ_CP046040:c1573231-1572755 [Streptococcus equi subsp. zooepidemicus]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEEKLLTPVEDYQLTLKVE
VIKERGAAILSELYCYQDSQGIAFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELARHQVVA

Nucleotide

• Length: 477 bp

>AT143438 NZ_CP061089:610887-611183 [Brucella sp. 6810]
ATGACCAATATCCTTCCTCCGGTCCACCCCGGCGAAATCCTTCGGGAAGAATATCTCATCCCGCTTGGTATGAGCGCGGG
CGCACTCGCCAAGCGTCTGAATGTCCCTCGCACACGCATCGAGCGTCTGGCTACAGAACAAACGAACGTCACCCCGGATA
CTGCCCTGCGCCTTGCCAAGTTCCTCCGCACTACGCCGGAATTCTGGATGAATATGCAGGCGAGTTATGACCTAAAAACG
GAGGCCGTCGCCATTCAGGACCAACTTGCAGCGATCCACGAGATGGAAGCTGCTTAA

Structures

Toxin

• AlphaFold DB: A0A6D2LV21