Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-doc
Location 7451..8055 Replicon plasmid unnamed1
Accession NZ_CP046029
Organism Staphylococcus chromogenes strain 1401

Toxin (Protein)


Gene name pemK Uniprot ID L7PFJ6
Locus tag GJU84_RS11655 Protein ID WP_001022435.1
Coordinates 7451..7789 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag GJU84_RS11660 Protein ID WP_165885982.1
Coordinates 7786..8055 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJU84_RS11620 2705..2950 - 246 WP_165885977.1 hypothetical protein -
GJU84_RS11625 3022..3333 - 312 WP_165885978.1 hypothetical protein -
GJU84_RS11630 4147..4374 + 228 WP_019167888.1 hypothetical protein -
GJU84_RS11635 4371..4643 + 273 WP_019167887.1 type II toxin-antitoxin system RelE/ParE family toxin -
GJU84_RS11640 4889..5149 + 261 WP_165885979.1 hypothetical protein -
GJU84_RS11645 5431..6105 + 675 WP_165885980.1 IS6 family transposase -
GJU84_RS11650 6593..7276 - 684 WP_165885981.1 CPBP family intramembrane metalloprotease -
GJU84_RS11655 7451..7789 - 339 WP_001022435.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GJU84_RS11660 7786..8055 - 270 WP_165885982.1 AbrB family transcriptional regulator Antitoxin
GJU84_RS11665 8620..9429 + 810 WP_165885983.1 alpha/beta hydrolase -
GJU84_RS11670 9542..10273 + 732 WP_000753929.1 CPBP family intramembrane metalloprotease -
GJU84_RS11675 10405..10686 + 282 WP_165886011.1 protein rep -
GJU84_RS11680 11695..12111 - 417 WP_165885984.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid msr(A) / mph(C) - 1..80178 80178
- flank IS/Tn - - 5431..6105 674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13001.20 Da        Isoelectric Point: 10.1988

>T143436 WP_001022435.1 NZ_CP046029:c7789-7451 [Staphylococcus chromogenes]
MNIKQFDILYIDLNPTRGREKHNVRPCLVINNQMSIDGTNFVWVLPITTRGLRYPTDIQLKTKKGLVSGVIDTVQIRALD
LKARQYNYKDELQDNLKNDILKAIKTYLKPTL

Download         Length: 339 bp

>T143436 NZ_CP061088:c326933-326637 [Brucella sp. 6810]
ATGGCCCTTGAAACCACTCGTTTCGATATTCTCGACCATCTCAAGACGCCGGAGGAGCGCCTTGCTTATCTCGAAGCAGC
ATTTGAGGATGGCGATCCTTCTCTTATCGCTCATGCCCTCGGCGATGTGGCCCGCTCCGTTGGGATGACTGCCGTTGCCA
AAGAAGCCGGCATTACCCGTGAGGCGCTTTATAGATCGCTCAGCGAAAACGGCGACCCGAAACTATCGACCTTGCTTGGC
GTTACCAAAGCCCTCGGCATTCATTTGACAGTCGGGCCAGACAAACACGCCGCCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10201.65 Da        Isoelectric Point: 10.1641

>AT143436 WP_165885982.1 NZ_CP046029:c8055-7786 [Staphylococcus chromogenes]
MSKSLKDLNKTSERVFKNGNSKAISLSKKTIRLANFDIGDTVEVQKMNGGLFITKKKESIEDRIKNFFQSGGKYTELEVD
WEERVGREI

Download         Length: 270 bp

>AT143436 NZ_CP061088:c327225-326935 [Brucella sp. 6810]
ATGATCGAAGTTCGCCAAACCACAGCATTCACAAAATGGCTCAACGAGCTTCGAGACACCAATGCGCGTTTAAGGATTGC
CACTCGTATCCGACGAATGGAGCTTGGCAATCCAGGTGATGTGAAAGCCGTTGGTGAAGGTGTGAGCGAGATGCGTATTA
CCTATGGTCAAGGCTATCGGGTTTATTTCGTGACCATGGGTTCAACCATTGTCGTTCTGTTATGTGGCGGTGACAAGTCA
TCACAAAGCCGGGATATTGCCGTGGCGAAACAAATGGCGAAGGAAATTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7EWJ
PDB 7EWI

Antitoxin

Source ID Structure

References