Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 4147..4643 Replicon plasmid unnamed1
Accession NZ_CP046029
Organism Staphylococcus chromogenes strain 1401

Toxin (Protein)


Gene name relE Uniprot ID A0A380FXC0
Locus tag GJU84_RS11635 Protein ID WP_019167887.1
Coordinates 4371..4643 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A380FYU1
Locus tag GJU84_RS11630 Protein ID WP_019167888.1
Coordinates 4147..4374 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJU84_RS11605 302..1261 - 960 WP_206187650.1 hypothetical protein -
GJU84_RS11610 1265..1693 - 429 WP_165885975.1 RusA family crossover junction endodeoxyribonuclease -
GJU84_RS11615 1704..2294 - 591 WP_165885976.1 hypothetical protein -
GJU84_RS11620 2705..2950 - 246 WP_165885977.1 hypothetical protein -
GJU84_RS11625 3022..3333 - 312 WP_165885978.1 hypothetical protein -
GJU84_RS11630 4147..4374 + 228 WP_019167888.1 hypothetical protein Antitoxin
GJU84_RS11635 4371..4643 + 273 WP_019167887.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJU84_RS11640 4889..5149 + 261 WP_165885979.1 hypothetical protein -
GJU84_RS11645 5431..6105 + 675 WP_165885980.1 IS6 family transposase -
GJU84_RS11650 6593..7276 - 684 WP_165885981.1 CPBP family intramembrane metalloprotease -
GJU84_RS11655 7451..7789 - 339 WP_001022435.1 type II toxin-antitoxin system PemK/MazF family toxin -
GJU84_RS11660 7786..8055 - 270 WP_165885982.1 AbrB family transcriptional regulator -
GJU84_RS11665 8620..9429 + 810 WP_165885983.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid msr(A) / mph(C) - 1..80178 80178
- flank IS/Tn - - 5431..6105 674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10566.39 Da        Isoelectric Point: 10.7655

>T143435 WP_019167887.1 NZ_CP046029:4371-4643 [Staphylococcus chromogenes]
MKYSLKISKKTNKTLSKIDKPTRNILLKWLYNNVHNSDNPRLHGKALQGELSNLWRYRVGKYRIIVEIQDDELVVLAIDV
GIRGSIYKRK

Download         Length: 273 bp

>T143435 NZ_CP061088:c228268-227978 [Brucella sp. 6810]
ATGATCGAAGTTCGCCAAACCACAGCATTCACAAAATGGCTCAACGAGCTTCGAGACACCAATGCGCGTTTAAGGATTGC
CACTCGTATCCGACGAATGGAGCTTGGCAATCCAGGTGATGTGAAAGCCGTGGGTGAAGGTGTGAGCGAGATGCGTATTA
CCTATGGCCCCGGCTATCGGGTTTATTTCGTGACCATGGGTTCAACCATTGTCGTTCTGTTATGTGGCGGTGACAAGTCA
TCACAAAGCCGGGATATTGCCGTGGCGAAACAAATGGCGAAGGAGATTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8891.13 Da        Isoelectric Point: 4.0948

>AT143435 WP_019167888.1 NZ_CP046029:4147-4374 [Staphylococcus chromogenes]
MATITIRISNDEKVFLKYMAKFLGLSLSEVLKQYTFEELEDIYDAKVGDEALIEYRETYQESIDIEDVMKQWDVK

Download         Length: 228 bp

>AT143435 NZ_CP061088:c227976-227680 [Brucella sp. 6810]
ATGGCCCTTGAAACCACTCGTTTCGATATTCTCGACCATCTCAAGACGCCGGAGGAGCGCCTTGCTTATCTCGAAGCAGC
ATTTGAGGATGGCGACCCTTCTCTTATCGCTCATGCCCTCGGCGATGTGGCCCGCTCCGTTGGTATGACTGCCGTTGCCA
AAGAAGCAGGCATTACCCGTGAGGCGCTTTACAGATCTCTCAGCGAAAATGGCGACCCGAAACTATCGACCTTGCTTGGC
GTTACCAAAGCCCTCGGCATTCATTTGACCGTCGGGCCAGACAAACACGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380FXC0

Antitoxin

Source ID Structure
AlphaFold DB A0A380FYU1

References