Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 4147..4643 Replicon plasmid unnamed1
Accession NZ_CP046029
Organism Staphylococcus chromogenes strain 1401

Toxin (Protein)


Gene name relE Uniprot ID A0A380FXC0
Locus tag GJU84_RS11635 Protein ID WP_019167887.1
Coordinates 4371..4643 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A380FYU1
Locus tag GJU84_RS11630 Protein ID WP_019167888.1
Coordinates 4147..4374 (+) Length 76 a.a.

Genomic Context

GJU84_RS11630GJU84_RS11635GJU84_RS11640GJU84_RS11645GJU84_RS11665GJU84_RS11605GJU84_RS11610GJU84_RS11615GJU84_RS11620GJU84_RS11625GJU84_RS11650GJU84_RS11655GJU84_RS11660
Location: 4147..4374 (228 bp)
Type: Antitoxin
Protein ID: WP_019167888.1
Location: 4371..4643 (273 bp)
Type: Toxin
Protein ID: WP_019167887.1
Location: 4889..5149 (261 bp)
Type: Others
Protein ID: WP_165885979.1
Location: 5431..6105 (675 bp)
Type: Others
Protein ID: WP_165885980.1
Location: 8620..9429 (810 bp)
Type: Others
Protein ID: WP_165885983.1
Location: 302..1261 (960 bp)
Type: Others
Protein ID: WP_206187650.1
Location: 1265..1693 (429 bp)
Type: Others
Protein ID: WP_165885975.1
Location: 1704..2294 (591 bp)
Type: Others
Protein ID: WP_165885976.1
Location: 2705..2950 (246 bp)
Type: Others
Protein ID: WP_165885977.1
Location: 3022..3333 (312 bp)
Type: Others
Protein ID: WP_165885978.1
Location: 6593..7276 (684 bp)
Type: Others
Protein ID: WP_165885981.1
Location: 7451..7789 (339 bp)
Type: Others
Protein ID: WP_001022435.1
Location: 7786..8055 (270 bp)
Type: Others
Protein ID: WP_165885982.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GJU84_RS11605302..1261-960WP_206187650.1hypothetical protein-
GJU84_RS116101265..1693-429WP_165885975.1RusA family crossover junction endodeoxyribonuclease-
GJU84_RS116151704..2294-591WP_165885976.1hypothetical protein-
GJU84_RS116202705..2950-246WP_165885977.1hypothetical protein-
GJU84_RS116253022..3333-312WP_165885978.1hypothetical protein-
GJU84_RS116304147..4374+228WP_019167888.1hypothetical proteinAntitoxin
GJU84_RS116354371..4643+273WP_019167887.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GJU84_RS116404889..5149+261WP_165885979.1hypothetical protein-
GJU84_RS116455431..6105+675WP_165885980.1IS6 family transposase-
GJU84_RS116506593..7276-684WP_165885981.1CPBP family intramembrane metalloprotease-
GJU84_RS116557451..7789-339WP_001022435.1type II toxin-antitoxin system PemK/MazF family toxin-
GJU84_RS116607786..8055-270WP_165885982.1AbrB family transcriptional regulator-
GJU84_RS116658620..9429+810WP_165885983.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidmsr(A) / mph(C)-1..8017880178
-flankIS/Tn--5431..6105674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10566.39 Da        Isoelectric Point: 10.7655

>T143435 WP_019167887.1 NZ_CP046029:4371-4643 [Staphylococcus chromogenes]
MKYSLKISKKTNKTLSKIDKPTRNILLKWLYNNVHNSDNPRLHGKALQGELSNLWRYRVGKYRIIVEIQDDELVVLAIDV
GIRGSIYKRK

Download         Length: 273 bp

>T143435 NZ_CP061088:c228268-227978 [Brucella sp. 6810]
ATGATCGAAGTTCGCCAAACCACAGCATTCACAAAATGGCTCAACGAGCTTCGAGACACCAATGCGCGTTTAAGGATTGC
CACTCGTATCCGACGAATGGAGCTTGGCAATCCAGGTGATGTGAAAGCCGTGGGTGAAGGTGTGAGCGAGATGCGTATTA
CCTATGGCCCCGGCTATCGGGTTTATTTCGTGACCATGGGTTCAACCATTGTCGTTCTGTTATGTGGCGGTGACAAGTCA
TCACAAAGCCGGGATATTGCCGTGGCGAAACAAATGGCGAAGGAGATTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8891.13 Da        Isoelectric Point: 4.0948

>AT143435 WP_019167888.1 NZ_CP046029:4147-4374 [Staphylococcus chromogenes]
MATITIRISNDEKVFLKYMAKFLGLSLSEVLKQYTFEELEDIYDAKVGDEALIEYRETYQESIDIEDVMKQWDVK

Download         Length: 228 bp

>AT143435 NZ_CP061088:c227976-227680 [Brucella sp. 6810]
ATGGCCCTTGAAACCACTCGTTTCGATATTCTCGACCATCTCAAGACGCCGGAGGAGCGCCTTGCTTATCTCGAAGCAGC
ATTTGAGGATGGCGACCCTTCTCTTATCGCTCATGCCCTCGGCGATGTGGCCCGCTCCGTTGGTATGACTGCCGTTGCCA
AAGAAGCAGGCATTACCCGTGAGGCGCTTTACAGATCTCTCAGCGAAAATGGCGACCCGAAACTATCGACCTTGCTTGGC
GTTACCAAAGCCCTCGGCATTCATTTGACCGTCGGGCCAGACAAACACGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A380FXC0

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A380FYU1

References