Detailed information of TA system TA143434

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 1887119..1887925
• Replicon: chromosome
• Accession: NZ_CP046028
• Organism: Staphylococcus chromogenes strain 1401

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: GJU84_RS09255
• Protein ID: WP_165885855.1
• Coordinates: 1887461..1887925 (+)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: GJU84_RS09250
• Protein ID: WP_107372887.1
• Coordinates: 1887119..1887448 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJU84_RS09200	1882707..1883207	-	501	WP_165885850.1	DUF669 domain-containing protein	-
GJU84_RS09205	1883224..1884558	-	1335	WP_165885851.1	DEAD/DEAH box helicase	-
GJU84_RS09210	1884542..1885252	-	711	WP_165885852.1	AAA family ATPase	-
GJU84_RS09215	1885252..1885470	-	219	WP_165885853.1	DUF2483 family protein	-
GJU84_RS09220	1885467..1885733	-	267	WP_157950523.1	DUF1108 family protein	-
GJU84_RS09225	1885815..1885991	-	177	WP_165885854.1	hypothetical protein	-
GJU84_RS09230	1885981..1886160	-	180	WP_107362511.1	hypothetical protein	-
GJU84_RS09235	1886261..1886500	+	240	WP_057510934.1	hypothetical protein	-
GJU84_RS09240	1886490..1886669	-	180	WP_057510935.1	hypothetical protein	-
GJU84_RS09245	1886682..1886927	-	246	WP_107372884.1	helix-turn-helix domain-containing protein	-
GJU84_RS09250	1887119..1887448	+	330	WP_107372887.1	helix-turn-helix domain-containing protein	Antitoxin
GJU84_RS09255	1887461..1887925	+	465	WP_165885855.1	ImmA/IrrE family metallo-endopeptidase	Toxin
GJU84_RS09260	1887941..1888477	+	537	WP_165885856.1	Ltp family lipoprotein	-
GJU84_RS09265	1888596..1889111	+	516	WP_165885857.1	hypothetical protein	-
GJU84_RS09270	1889173..1890222	+	1050	WP_165885858.1	site-specific integrase	-
GJU84_RS09275	1890290..1891687	-	1398	WP_037572364.1	Fe-S cluster assembly protein SufB	-
GJU84_RS09280	1891762..1892211	-	450	WP_037572365.1	SUF system NifU family Fe-S cluster assembly protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1842949..1908747	65798

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• IrrE N-terminal-like domain (32-116)

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-65)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 18282.81 Da
• Isoelectric Point: 6.4964

>T143434 WP_165885855.1 NZ_CP046028:1887461-1887925 [Staphylococcus chromogenes]
MGLYEETLIQHDYIEVREANVLPDNLDGVWLGDLILIKRNLPEKKKVEVLFEELAHHKLTYGDITDQKKFNNRKFENYAR
RYSYETSMPLSGIVEAFKQGVHNLYELANFFEISEGHVLDCIEHYKKKHGLSTFNEGHLIQFEPLRVFKYKNYQ

Nucleotide

• Length: 465 bp

>T143434 NZ_CP061088:c227976-227680 [Brucella sp. 6810]
ATGGCCCTTGAAACCACTCGTTTCGATATTCTCGACCATCTCAAGACGCCGGAGGAGCGCCTTGCTTATCTCGAAGCAGC
ATTTGAGGATGGCGACCCTTCTCTTATCGCTCATGCCCTCGGCGATGTGGCCCGCTCCGTTGGTATGACTGCCGTTGCCA
AAGAAGCAGGCATTACCCGTGAGGCGCTTTACAGATCTCTCAGCGAAAATGGCGACCCGAAACTATCGACCTTGCTTGGC
GTTACCAAAGCCCTCGGCATTCATTTGACCGTCGGGCCAGACAAACACGCCGCCTGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12766.37 Da
• Isoelectric Point: 7.3179

>AT143434 WP_107372887.1 NZ_CP046028:1887119-1887448 [Staphylococcus chromogenes]
MRNNDEIITIIKTSMKEQNLSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKALSISTEYLLGFEKSEQKHEQPQH
RAAHLEGELTDDEWQRVLDYADYIRSRRK

Nucleotide

• Length: 330 bp

>AT143434 NZ_CP061088:c228268-227978 [Brucella sp. 6810]
ATGATCGAAGTTCGCCAAACCACAGCATTCACAAAATGGCTCAACGAGCTTCGAGACACCAATGCGCGTTTAAGGATTGC
CACTCGTATCCGACGAATGGAGCTTGGCAATCCAGGTGATGTGAAAGCCGTGGGTGAAGGTGTGAGCGAGATGCGTATTA
CCTATGGCCCCGGCTATCGGGTTTATTTCGTGACCATGGGTTCAACCATTGTCGTTCTGTTATGTGGCGGTGACAAGTCA
TCACAAAGCCGGGATATTGCCGTGGCGAAACAAATGGCGAAGGAGATTTAA