Detailed information of TA system TA143433

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 919156..919937
• Replicon: chromosome
• Accession: NZ_CP046028
• Organism: Staphylococcus chromogenes strain 1401

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: GJU84_RS04435
• Protein ID: WP_157946077.1
• Coordinates: 919773..919937 (+)
• Length: 55 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: GJU84_RS04430
• Protein ID: WP_105986518.1
• Coordinates: 919156..919755 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJU84_RS04410	915349..916071	+	723	WP_037577247.1	amino acid ABC transporter ATP-binding protein	-
GJU84_RS04415	916359..917492	+	1134	WP_165885573.1	tRNA epoxyqueuosine(34) reductase QueG	-
GJU84_RS04420	917489..917959	+	471	WP_165885574.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
GJU84_RS04425	917977..919137	+	1161	WP_165885575.1	N-acetylglucosamine-6-phosphate deacetylase	-
GJU84_RS04430	919156..919755	+	600	WP_105986518.1	glucosamine-6-phosphate isomerase	Antitoxin
GJU84_RS04435	919773..919937	+	165	WP_157946077.1	hypothetical protein	Toxin
GJU84_RS04440	920037..920447	+	411	WP_103159619.1	hypothetical protein	-
GJU84_RS04445	920592..921977	+	1386	WP_037577233.1	class II fumarate hydratase	-
GJU84_RS04450	921999..923525	+	1527	WP_165885576.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (135-197)

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 6336.67 Da
• Isoelectric Point: 3.8825

>T143433 WP_157946077.1 NZ_CP046028:919773-919937 [Staphylococcus chromogenes]
MTEEKHIEHENEMVDDFDDLVSLGKEMEQISEANDEEKENQTHDASIRSDKTEE

Nucleotide

• Length: 165 bp

>T143433 NZ_CP061088:136767-137171 [Brucella sp. 6810]
TTGAGCAAGCTTTACATGCTGGACACCAACATCGTGTCGGATCTTGCTCGTAACCCTCATGGCCCTGTAGCAAAACATAT
CGCTCGCGTGGGGGCTGATGCGATTTGCGTAAGCATCATTACCGCCTGCGAACTGCGTTACGGTTGTGCGAAAAAGGGTT
CGCCAAGACTGCTCGCACAGATAGAGGCAATACTGGATAGCATTGAAATTCTGCCGCTCGATGTTCCTGCCGATACGGAG
TATGGGGGCATACGGGCAGAACTGGAAGCTGATGGAAAGCCTATCGGTCCCAATGACTTTCTTATCGCGGCTCACGCTTG
CGCACTCGGTGCGGTTCTGGTTACGGCCAATGTCGGTGAGTTTACCCGCATCCGTAAACTTGCTGTTGAAAACTGGTTGA
ATTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22354.27 Da
• Isoelectric Point: 5.8826

>AT143433 WP_105986518.1 NZ_CP046028:919156-919755 [Staphylococcus chromogenes]
MAMNFKVFKDKDTAAIYAADIIRKQFNNNPTTIAGFHLSGEEAPVLDYLKRNVDDHAVDFSQIHVLDYDKQTSYFKALGV
PEKQIHEIPEDDDVEKFIEHKAKTKDNKGKLTLQVVSINQNGEFGVPVNNGLKPAREIFVIVTGHDKADVIKKLYEDNGN
TSFIPSSLKTHRMVNVILDEAAAQGLPADVREYFTSLYA

Nucleotide

• Length: 600 bp

>AT143433 NZ_CP061088:136501-136770 [Brucella sp. 6810]
ATGGCACACGCAAGACGTATCGAGCCAACGCCTGCGCGCGAGGCAAAGCTTTTTCGCAACAATAAGAGTCAGGCAGTTCG
TATTCCGGCTGATTTTGAGTTTCCGGGGAACCGTGTGCTTATCCATCGTGAAGGGGACAAGCTCATCATTGAACCTGTTC
GCCGAAAGAATCTGCTCGAAGTACTGGCAGGATTAAAGCCTCTTGGACCAGAGGACGCTTTCCCGGACATTGATGATACA
GCCCTCCCGCTTAAGGATGTAGACCTTTGA