Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 778511..779035 Replicon chromosome
Accession NZ_CP046028
Organism Staphylococcus chromogenes strain 1401

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GJU84_RS03630 Protein ID WP_103159488.1
Coordinates 778682..779035 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A3A0K2V6
Locus tag GJU84_RS03625 Protein ID WP_037577177.1
Coordinates 778511..778681 (+) Length 57 a.a.

Genomic Context

GJU84_RS03600GJU84_RS03605GJU84_RS03610GJU84_RS03615GJU84_RS03620GJU84_RS03625GJU84_RS03630GJU84_RS03635GJU84_RS03640GJU84_RS03645GJU84_RS03650
Location: 774359..774832 (474 bp)
Type: Others
Protein ID: WP_145400619.1
Location: 774825..776303 (1479 bp)
Type: Others
Protein ID: WP_145400620.1
Location: 776300..776815 (516 bp)
Type: Others
Protein ID: WP_165885554.1
Location: 776812..777162 (351 bp)
Type: Others
Protein ID: WP_145400622.1
Location: 777278..778426 (1149 bp)
Type: Others
Protein ID: WP_165885555.1
Location: 778511..778681 (171 bp)
Type: Antitoxin
Protein ID: WP_037577177.1
Location: 778682..779035 (354 bp)
Type: Toxin
Protein ID: WP_103159488.1
Location: 779099..780103 (1005 bp)
Type: Others
Protein ID: WP_145400623.1
Location: 780184..780510 (327 bp)
Type: Others
Protein ID: WP_145400624.1
Location: 780513..780992 (480 bp)
Type: Others
Protein ID: WP_037577169.1
Location: 780967..781737 (771 bp)
Type: Others
Protein ID: WP_037577167.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GJU84_RS03600774359..774832+474WP_145400619.1PH domain-containing protein-
GJU84_RS03605774825..776303+1479WP_145400620.1PH domain-containing protein-
GJU84_RS03610776300..776815+516WP_165885554.1PH domain-containing protein-
GJU84_RS03615776812..777162+351WP_145400622.1holo-ACP synthase-
GJU84_RS03620777278..778426+1149WP_165885555.1alanine racemase-
GJU84_RS03625778511..778681+171WP_037577177.1hypothetical proteinAntitoxin
GJU84_RS03630778682..779035+354WP_103159488.1type II toxin-antitoxin system PemK/MazF family toxinToxin
GJU84_RS03635779099..780103+1005WP_145400623.1PP2C family protein-serine/threonine phosphatase-
GJU84_RS03640780184..780510+327WP_145400624.1anti-sigma factor antagonist-
GJU84_RS03645780513..780992+480WP_037577169.1anti-sigma B factor RsbW-
GJU84_RS03650780967..781737+771WP_037577167.1RNA polymerase sigma factor SigB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13064.34 Da        Isoelectric Point: 10.5127

>T143432 WP_103159488.1 NZ_CP046028:778682-779035 [Staphylococcus chromogenes]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIDKKKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSDKKMKEVNAALGISLGLHMNQHK

Download         Length: 354 bp

>T143432 NZ_CP061087:c1280559-1279813 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCACCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGTCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6328.01 Da        Isoelectric Point: 4.2313

>AT143432 WP_037577177.1 NZ_CP046028:778511-778681 [Staphylococcus chromogenes]
MSAFNQTRVKSLEQSLKEGYVQMADLNLSLATEAYFVECEACDCNESHLLSNHKDD

Download         Length: 171 bp

>AT143432 NZ_CP061087:c1279812-1279642 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3A0K2V6

References