Detailed information of TA system TA143431

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2521058..2521804
• Replicon: chromosome
• Accession: NZ_CP046027
• Organism: Neisseria brasiliensis strain N.177.16

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: GJV52_RS12620
• Protein ID: WP_100562742.1
• Coordinates: 2521058..2521525 (-)
• Length: 156 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: GJV52_RS12625
• Protein ID: WP_100562697.1
• Coordinates: 2521538..2521804 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJV52_RS12595	2516912..2517463	-	552	Protein_2433	GNAT family N-acetyltransferase	-
GJV52_RS12600	2517454..2517756	-	303	WP_100562705.1	DUF1778 domain-containing protein	-
GJV52_RS12605	2517900..2519168	-	1269	WP_100562703.1	three-Cys-motif partner protein TcmP	-
GJV52_RS12610	2519213..2519944	-	732	WP_100562701.1	phage Gp37/Gp68 family protein	-
GJV52_RS12615	2520091..2520975	+	885	WP_100562699.1	SprT-like domain-containing protein	-
GJV52_RS12620	2521058..2521525	-	468	WP_100562742.1	GNAT family N-acetyltransferase	Toxin
GJV52_RS12625	2521538..2521804	-	267	WP_100562697.1	DUF1778 domain-containing protein	Antitoxin
GJV52_RS12630	2522038..2522733	+	696	WP_100562695.1	recombinase family protein	-
GJV52_RS12635	2522921..2523487	-	567	WP_154212912.1	RNA 2'-phosphotransferase	-
GJV52_RS12640	2523518..2523913	-	396	WP_100562691.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2419442..2545159	125717

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (42-142)

Antitoxin

• Vibrio phage ICP1, Orf50 (7-81)

Sequences

Toxin

Protein

• Length: 156 a.a.
• Molecular weight: 16905.50 Da
• Isoelectric Point: 9.1860

>T143431 WP_100562742.1 NZ_CP046027:c2521525-2521058 [Neisseria brasiliensis]
MTAPELLNDTHCLDGFNCGVASLNEWLVKSALKNQNSNASRTFVVCNQAGSVVGYYCLAAGSLTHEEAIGSFRRNMPSPI
PVIVLGRLAVDVRAQGKELGKSLLRDAFLRAYKISQHLGARGLLVHAISEEARQFYLKNGFTASPISPYTLMHKL

Nucleotide

• Length: 468 bp

>T143431 NZ_CP061087:522104-522454 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAGAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9931.36 Da
• Isoelectric Point: 4.4143

>AT143431 WP_100562697.1 NZ_CP046027:c2521804-2521538 [Neisseria brasiliensis]
MLKTAPINLRALEAQKNLIDQAAALLGKTRSEFILEASCSAAENTLMDKTVFSLTSDEYQQFIHLLEQPTEPNDGFEKLM
SMTPVWER

Nucleotide

• Length: 267 bp

>AT143431 NZ_CP061087:521817-522098 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA