Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2506224..2506852 Replicon chromosome
Accession NZ_CP046027
Organism Neisseria brasiliensis strain N.177.16

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GJV52_RS12530 Protein ID WP_100562743.1
Coordinates 2506224..2506619 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GJV52_RS12535 Protein ID WP_100562731.1
Coordinates 2506622..2506852 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJV52_RS12500 2501321..2501596 - 276 WP_100563983.1 hypothetical protein -
GJV52_RS12505 2501607..2502518 - 912 WP_100563981.1 phasyl DNA replicon protein arp -
GJV52_RS12515 2502745..2503422 - 678 WP_095503842.1 IS1595-like element ISNme3 family transposase -
GJV52_RS12520 2503611..2504312 - 702 WP_100562735.1 DUF4400 domain-containing protein -
GJV52_RS12525 2504302..2506047 - 1746 Protein_2418 type IV conjugative transfer system coupling protein TraD -
GJV52_RS12530 2506224..2506619 - 396 WP_100562743.1 type II toxin-antitoxin system VapC family toxin Toxin
GJV52_RS12535 2506622..2506852 - 231 WP_100562731.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GJV52_RS12540 2507065..2508579 + 1515 WP_100562729.1 conjugal transfer protein TraH -
GJV52_RS12545 2508591..2511665 + 3075 WP_100562727.1 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2419442..2545159 125717
- flank IS/Tn - - 2502745..2503422 677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(7-42)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14895.20 Da        Isoelectric Point: 5.6614

>T143430 WP_100562743.1 NZ_CP046027:c2506619-2506224 [Neisseria brasiliensis]
IKYLLDTNICIYIINQKPKYVFEKFEEYNPGEIAVSSITACELAFGVEKSGSLKNRAALEKFLVPLDVLPFDESAIWHYA
RIRQHLQSKGTPIGLDLLIAAHALSLNVPLVSNNTKEFERVEGLYLENWIQ

Download         Length: 396 bp

>T143430 NZ_CP061085:98312-98566 [Pantoea sp. MT58]
GTGAAACTGACCTGGTCCGCAGAAGCCTGGGAAGATTATCTGTACTGGCAGGATACTGATAAAAAAACCGTCAAAAAGAT
TAACGAACTCCTTAAAGATGCCAGCAGGACGCCTTTTGAAGGCAAGGGAAAACCCGAGCCCCTGAAGCATAATCTTGCGG
GATTCTGGTCCCGCAGGATTACGGCGGAACATCGACTGGTCTACGCCGTCACTGAGGAGGCATTATTAATCGCCTCATGC
CGTTATCACTACTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8671.90 Da        Isoelectric Point: 5.8257

>AT143430 WP_100562731.1 NZ_CP046027:c2506852-2506622 [Neisseria brasiliensis]
MQTAKIFTTGRSQAVRLPKAFQFDGREVFIKHFAGGVLLIPKEKSWQSMAEAVGEFESDFVLQREAQPEQSREEIL

Download         Length: 231 bp

>AT143430 NZ_CP061085:98064-98315 [Pantoea sp. MT58]
ATGAGAGCAATCAGTTACAGCGAAGCCAGACAGAATCTTTCTGCCACGATGGTTCAGACAGTTGAAGATAAGGCACCGGT
GTTAATCACTCGCCAGAACGGCGAATCCTGCGTGCTGATGTCGCTTGATGAATATAACTCACTGGAAGAGACGGCCTATC
TGCTGCGTTCGCCTAAGAATGCTCGCAGATTGATGGATGCTATCGAAAGCCTGCAAAGCGGTAAAGGGACTGACAGGGAT
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References