Detailed information of TA system TA143427

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 389969..390477
• Replicon: chromosome
• Accession: NZ_CP046027
• Organism: Neisseria brasiliensis strain N.177.16

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: GJV52_RS02100
• Protein ID: WP_095503318.1
• Coordinates: 390214..390477 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GJV52_RS02095
• Protein ID: WP_195690059.1
• Coordinates: 389969..390217 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJV52_RS02065	385348..386103	-	756	WP_100564403.1	conjugal transfer protein TraL	-
GJV52_RS02070	386254..386784	-	531	WP_100564405.1	conjugal transfer protein TrbM	-
GJV52_RS13065	386910..387086	-	177	WP_195690058.1	hypothetical protein	-
GJV52_RS02075	387485..388054	+	570	WP_154212844.1	hypothetical protein	-
GJV52_RS02080	388002..388424	-	423	WP_100564407.1	hypothetical protein	-
GJV52_RS02085	388421..388645	-	225	WP_154212845.1	PbsX family transcriptional regulator	-
GJV52_RS02090	388687..389646	-	960	WP_154212846.1	IS30 family transposase	-
GJV52_RS02095	389969..390217	+	249	WP_195690059.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GJV52_RS02100	390214..390477	+	264	WP_095503318.1	Txe/YoeB family addiction module toxin	Toxin
GJV52_RS02105	390517..390894	-	378	WP_095503317.1	hypothetical protein	-
GJV52_RS02110	391561..391959	+	399	WP_100564589.1	phosphoglycerate kinase	-
GJV52_RS02115	392026..392358	+	333	WP_095503324.1	molybdenum ABC transporter ATP-binding protein	-
GJV52_RS02120	392360..392716	+	357	WP_095503315.1	hypothetical protein	-
GJV52_RS02125	392767..393210	+	444	WP_095503314.1	hypothetical protein	-
GJV52_RS02130	393200..393553	+	354	WP_095503313.1	hypothetical protein	-
GJV52_RS02135	393882..394694	+	813	WP_100564587.1	ShlB/FhaC/HecB family hemolysin secretion/activation protein	-
GJV52_RS02140	394764..395180	-	417	WP_095503171.1	IS200/IS605 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	394764..395180	416

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-75)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10425.88 Da
• Isoelectric Point: 10.2939

>T143427 WP_095503318.1 NZ_CP046027:390214-390477 [Neisseria brasiliensis]
VRVHRFTESAAEDLAYWKKHDLKKVERIKALLDDIKANHPRGIGKPEQLRHQKSGLWSRRIDREHRLVYSVEENTVTVYA
CRYHYGR

Nucleotide

• Length: 264 bp

>T143427 NZ_CP061083:3071294-3071509 [Pantoea sp. MT58]
ATGAACAAAACCCTGACTAAAACTGATTATTTGATGCGACTACGGCGTTGCCGTTCACTTGATACCCTGGAAAGGGTCAT
TGAAAAAAATAAGTATGAATTACCTGAAGATGAGTTAGCGGTATTTTACTCGGCAGCTGACCATCGTCTGGCAGAACTGA
CGATGAACAAGCTTTACGATAAAGTCCCGGGTTCAGTCTGGAAATTTGTCCGCTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9241.35 Da
• Isoelectric Point: 4.2969

>AT143427 WP_195690059.1 NZ_CP046027:389969-390217 [Neisseria brasiliensis]
MNHVISYTSAREDLANIMTRVCEDQVVTHITRRNGGNCVLMSEEEYSSIMETLYLFGNPANASRLEQSIAEAEQGKFVEV
EL

Nucleotide

• Length: 249 bp

>AT143427 NZ_CP061083:3070892-3071269 [Pantoea sp. MT58]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATACCTATGTGAAAGCCTGTTTGACGACAGCATGGC
AACATTAACCGACAGCCATCATGGCTGGGTAAATGATCCCACTTCTGAAAGCAATCTGCAGCTTAACGATTTGATTGAGC
ACATCGCCTCTTTCACCATGAATTACAAAATTAAGCACGTTGAAGATGAAGCGCTGATTTCGCAAATCGATGAATATCTT
GATGATACCTTTATGTTATTCAGCAACTATGGTGTCAATAGTCCGGATCTTCAACGGTGGCAACGTTCAGCTAAACGCTT
ATTTAATCTGTTCACTGAAGAGTGCGCTTTTCTCCAGCAACCGAGCCATTCATTATAG