Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2377422..2378060 Replicon chromosome
Accession NZ_CP046025
Organism Escherichia coli strain C439

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag GJH08_RS11445 Protein ID WP_000813794.1
Coordinates 2377884..2378060 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GJH08_RS11440 Protein ID WP_001270286.1
Coordinates 2377422..2377838 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJH08_RS11420 2372574..2373515 - 942 WP_001251304.1 ABC transporter permease -
GJH08_RS11425 2373516..2374529 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
GJH08_RS11430 2374547..2375692 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
GJH08_RS11435 2375937..2377343 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
GJH08_RS11440 2377422..2377838 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
GJH08_RS11445 2377884..2378060 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
GJH08_RS11450 2378282..2378512 + 231 WP_000494244.1 YncJ family protein -
GJH08_RS11455 2378604..2380565 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
GJH08_RS11460 2380638..2381174 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
GJH08_RS11465 2381227..2382441 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T143416 WP_000813794.1 NZ_CP046025:c2378060-2377884 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T143416 NZ_CP061082:450325-450609 [Serratia liquefaciens]
ATGCGTGTCGAATGGGATGAAGAAGCGCTACGGGACAGGGAACGTATTTTTGATTTTCTCTATCCTTTTAATCCACAGGT
TGCTGAGCAGGCTGATGCTGAGATTGATAAGGCAGTGAAGCGCCTGTTGGATTACCCTGAACTCGGTAAAATTTGGTACA
GACAGGCGCGTAAGTTATTGGTCAGCCAGGCTTCGTTATTAGTTTTATACGTTGTTGTCGACGACGTGATTAAGGTTTTA
GCCGTTGCTCATCAACGAGAGAAATTCCCCGACATAGAGAACTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT143416 WP_001270286.1 NZ_CP046025:c2377838-2377422 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT143416 NZ_CP061082:450029-450316 [Serratia liquefaciens]
ATGGAAAGCCGTATCCAGTTTCGCATTGAGGATGAGACTAAACGTTTGGCGCAGAAAGCCGCAGAAGCCAAGGGGATCAC
TTTGAGTGAGGCGTGTCGACGTTTGGCTGAGCAAATGGCGGATGAGCAACGGGCCACTGAGCAACATGAAAATTGGTTGA
AAGAAAAGGTTGATGCCGCTTTTGCCCGTTTGCATGAAGGAAGTGCGGTCTATCTTGACCAGCAACAGGTTGATGAAAGC
ATGGATGCCTTTAAGGCAAAAGTCCGAGCGAAATACGACCGAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References