143381

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 1557404..1557975 Replicon chromosome
Accession NZ_CP046022
Organism Enterococcus faecalis strain BFF1B1

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag GIO26_RS07320 Protein ID WP_002360937.1
Coordinates 1557634..1557975 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag GIO26_RS07315 Protein ID WP_002354773.1
Coordinates 1557404..1557634 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIO26_RS07295 1553732..1555027 + 1296 WP_010820355.1 AAA family ATPase -
GIO26_RS07300 1555036..1555668 + 633 WP_207578862.1 RloB domain-containing protein -
GIO26_RS07305 1555735..1556727 - 993 WP_081115774.1 biotin--[acetyl-CoA-carboxylase] ligase -
GIO26_RS07310 1556866..1557081 + 216 WP_002354768.1 zinc ribbon domain-containing protein -
GIO26_RS07315 1557404..1557634 + 231 WP_002354773.1 hypothetical protein Antitoxin
GIO26_RS07320 1557634..1557975 + 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GIO26_RS07325 1558346..1561960 + 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T143381 WP_002360937.1 NZ_CP046022:1557634-1557975 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

>T143381 NZ_CP061079:c1505395-1505096 [Pseudomonas chlororaphis]
ATGCACGTTGAGTGGCTGCGCAGCGCCCTCAAGAACCTCGATGACGAAGCCGCCTACATTGCACAGGACAGTCCTCAGGC
CGCCGCGGAATTCGTCAAAGCCATCCTGAGTAGCATTCAACACCTGAGCCGTTTTCCTGCCAGTGGTCGCGAAGGTCGCC
TGCCCGGTACCCGGGAGTGGGTGGTCCCCAATCGTCCTTACCTGATCCCCTACCGCGTACGTCAGGGACGCCTGCAGATA
CTGCGGATTTTCCACACCCGGCGCTTGCCGCCTGCCGGTTGGCAAGACGACCGCCAATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT143381 WP_002354773.1 NZ_CP046022:1557404-1557634 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp

>AT143381 NZ_CP061079:c1505624-1505385 [Pseudomonas chlororaphis]
ATGTCCGTCATGTCCTTGCGCCTGCCCGATGATGTTGCCGATACCCTGGCTCACTTGGCCAAGGCGACAGGCCGCAGCAA
GTCATTCCTCGCTGTGGATGCACTGAGAGAATATCTGGCCCGCGAAGCCTGGCAAATCAACGAGATCCAGAAAGCCCTGA
CTGAAGCAGAGGCAGGCGACTTCGCCAGCGCCGAAGAGCTGGATGGCGTACTCAACAAATGGACTGGCAATGCACGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References