Detailed information of TA system TA143368

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 4088902..4089458
• Replicon: chromosome
• Accession: NZ_CP046019
• Organism: Xanthomonas citri pv. malvacearum strain HD-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GH913_RS17830
• Protein ID: WP_033836591.1
• Coordinates: 4088902..4089192 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: GH913_RS17835
• Protein ID: WP_004541313.1
• Coordinates: 4089180..4089458 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GH913_RS17810	4085272..4087275	+	2004	Protein_3485	TAL effector repeat-containing protein	-
GH913_RS17815	4087387..4087922	-	536	Protein_3486	transposase	-
GH913_RS17820	4088135..4088314	-	180	WP_015463309.1	hypothetical protein	-
GH913_RS17825	4088585..4088905	-	321	WP_099522003.1	hypothetical protein	-
GH913_RS17830	4088902..4089192	-	291	WP_033836591.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GH913_RS17835	4089180..4089458	-	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
GH913_RS23265	4089539..4089971	-	433	Protein_3491	relaxase	-
GH913_RS17840	4089943..4090104	-	162	WP_108350140.1	hypothetical protein	-
GH913_RS17845	4090180..4091336	+	1157	WP_089504557.1	IS3 family transposase	-
GH913_RS17850	4091840..4092055	+	216	Protein_3494	SAM-dependent DNA methyltransferase	-
GH913_RS17855	4092578..4093665	+	1088	WP_089504397.1	IS3-like element ISXac2 family transposase	-
GH913_RS23270	4093752..4093919	+	168	WP_005913009.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4079698..4090467	10769
	-	inside	IScluster/Tn	-	-	4081427..4093665	12238

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10858.43 Da
• Isoelectric Point: 9.9308

>T143368 WP_033836591.1 NZ_CP046019:c4089192-4088902 [Xanthomonas citri pv. malvacearum]
MPQVIFAPAAIGDMQRLREFLKPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRHAG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T143368 NZ_CP061071:166372-166704 [Streptococcus mutans B04Sm5]
ATGGTAACCATCAAGCAAGGGTCAATTATCAAAATTAACTTGGATCCCAAACAAGGACATGAACAAAAAGGGTATCGTCC
GTACATTTGTCTAAACCATAGTATCGTAACCAAGTATTCTAATATTGCTATTTTTGCGCCAATTAGCAATACCAAGCGTG
ATTATCCTTTTTATGTTTCCCTAGAAGGAACAGAATCCACAGGGAAAGTATTATTAGACCAACTGGTTACAATCGATTTT
AATGCTAGAGATTATCGTTATGTGGAGGATATTCAGGAAGACTTATTAGATGAACTTTTAGCTAGGGTCAAGGTGCTATT
TGAAAAAGGATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT143368 WP_004541313.1 NZ_CP046019:c4089458-4089180 [Xanthomonas citri pv. malvacearum]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT143368 NZ_CP061071:166133-166378 [Streptococcus mutans B04Sm5]
ATGCAACTAGTCATCAATAAATGGGGAAATAGCTCCGCTATTCGTTTGCCAAAACAATTGGTACAAGAATTACAATTACA
AACAAATGATGTCTTAGACTATAAGGTATCAGGGAATAAAATTATCCTAGAAAAAGTGAATAATGTCCCTGAATTAACTG
TAGAAGATCTGTTTAAAGATTATCAAGGTGAACCTGTCAATGTTACCCCAGTTCTATTTGAAAGTGTGGGAAATGAACAA
TGGTAA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0