Detailed information of TA system TA143367

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1009600..1010144
• Replicon: chromosome
• Accession: NZ_CP046019
• Organism: Xanthomonas citri pv. malvacearum strain HD-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7X9UUA0
• Locus tag: GH913_RS04345
• Protein ID: WP_033479617.1
• Coordinates: 1009600..1009899 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A828YMS8
• Locus tag: GH913_RS04350
• Protein ID: WP_005912560.1
• Coordinates: 1009887..1010144 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GH913_RS04315	1005135..1006222	+	1088	WP_089504397.1	IS3-like element ISXac2 family transposase	-
GH913_RS04320	1006262..1006489	-	228	Protein_849	hypothetical protein	-
GH913_RS04325	1006688..1007599	-	912	WP_005912568.1	LysR family transcriptional regulator	-
GH913_RS04330	1007725..1008462	+	738	WP_005912566.1	SDR family oxidoreductase	-
GH913_RS04335	1008521..1009420	+	900	WP_033836121.1	SDR family NAD(P)-dependent oxidoreductase	-
GH913_RS04345	1009600..1009899	-	300	WP_033479617.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GH913_RS04350	1009887..1010144	-	258	WP_005912560.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GH913_RS04355	1010211..1010873	-	663	WP_005912558.1	hemolysin III family protein	-
GH913_RS04360	1011051..1013546	+	2496	WP_165690593.1	DEAD/DEAH box helicase	-
GH913_RS04365	1013543..1015006	+	1464	WP_005921792.1	ribonuclease H-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11246.00 Da
• Isoelectric Point: 9.7235

>T143367 WP_033479617.1 NZ_CP046019:c1009899-1009600 [Xanthomonas citri pv. malvacearum]
MAEIIWSVPALADLDAIADYIAIDNAPAAAALVKRVFAHVEQLIEHPDSGSRPQELKRSRYRQIVEPPCRVFYRVDGQRI
VVVHVMRSERALRGNRLSR

Nucleotide

• Length: 300 bp

>T143367 NZ_CP061071:163403-163918 [Streptococcus mutans B04Sm5]
ATGTTTGACCTTGTTGTTAATTTGATTTTATTGGTTATTGTGATAGGTGGATTTGTCTTCTTAAGATTCTATGCGGATAA
GAAAGGCAAGCGAGAATACGATGAACGCCAGTTACTTATGCAAAAGAAAGCTTATACCAATGCGGCTTGGGTTGTTATGG
GTTTCAATCTTGTTCTTGTGATATGGGGTGAAGTGTTAGCAAAATATATCTCGCTATCCTTTGCAGGTACTGCCAATCTC
TTTCTTATCGTAGGCGTCTTTGTCTGCAGCAGTATCTTAAACGATGCTTATTTCACAGCAAGAAAAAACAAAAAATTCCT
CTATGTGTATGCCGTTATTATTGCTATTCAAATTTTCACTGTTTATCAAAATTGGAGTCAAGGCAGCTTTGGTCATGACG
GACATATTTATCTAACAGGAGAAAAAGCAATGAGTTTATTGTTTATCTTGACTTTTGCTGTCATTTTTCTAGTAACTGCT
TATAAAACGATTCAGGATAAGAGAGAGGGAAAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9646.15 Da
• Isoelectric Point: 8.6223

>AT143367 WP_005912560.1 NZ_CP046019:c1010144-1009887 [Xanthomonas citri pv. malvacearum]
MRTELVTTLKRQATELLAAAERDKEPILITQHGLPSAYLVDVASYERMQQRIALLEGIARGEMAVAEGRTLSHEQAQQRM
ARWLK

Nucleotide

• Length: 258 bp

>AT143367 NZ_CP061071:163918-164364 [Streptococcus mutans B04Sm5]
ATGAAAATGGAAAAGTCAAATAAACAAGTCATTTACGATGAACGTCAGCAGCAAATTCAACTTAAAAGTTATAGTCTTTC
ATTTTGGTTTGTTATGTTTATACTCTATTTTGCAACTTTTGGAAAGACTGATTTGTTGCTTAATATCGCTTTTTGGGGAG
GACTTGTTCTTAATTTTTGCTACAGTACTCTAAGAGGTGTTGGTCCTTTTGTTGATCCACGTTTTGGAAAAATTGCAAAA
ATCGGTCGTTTGGCCGCTGTTCCCCTTATTTTTTTGGGAATGCTAGTCTTTCTTGTTGCTATCATAATGTCTATTCTAGA
ACATGATAGTTTAAGAGAATCTATCATAAAATGCTCCTACTTAGGCTTATCTGGTTTTTGGCTAATTTGTATGGGAGCAA
GTATCGTCTACCGTCATTATCTTGATAAGAAAGAAGCAGACAAATGA

Structures

Toxin

• AlphaFold DB: A0A7X9UUA0

Antitoxin

• AlphaFold DB: A0A828YMS8