Detailed information of TA system TA143365

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 880890..881427
• Replicon: chromosome
• Accession: NZ_CP046019
• Organism: Xanthomonas citri pv. malvacearum strain HD-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7X9YU06
• Locus tag: GH913_RS03705
• Protein ID: WP_017158383.1
• Coordinates: 881146..881427 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7X9UWY6
• Locus tag: GH913_RS03700
• Protein ID: WP_017158384.1
• Coordinates: 880890..881159 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GH913_RS03675	876151..876849	+	699	WP_078538983.1	AAA family ATPase	-
GH913_RS03680	876873..877154	+	282	WP_017161425.1	hypothetical protein	-
GH913_RS03685	877706..878077	+	372	Protein_722	recombinase family protein	-
GH913_RS03690	878475..879620	+	1146	WP_025990656.1	DUF4236 domain-containing protein	-
GH913_RS03695	880335..880781	+	447	WP_089504520.1	resolvase	-
GH913_RS03700	880890..881159	+	270	WP_017158384.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GH913_RS03705	881146..881427	+	282	WP_017158383.1	type II toxin-antitoxin system YafQ family toxin	Toxin
GH913_RS03710	881565..881918	-	354	WP_017154897.1	hypothetical protein	-
GH913_RS03715	881966..882661	-	696	WP_017158799.1	hypothetical protein	-
GH913_RS03720	882670..883116	-	447	WP_017166397.1	hypothetical protein	-
GH913_RS03725	883475..883870	+	396	WP_017164031.1	hypothetical protein	-
GH913_RS03730	883968..884237	+	270	WP_154138446.1	antitoxin of toxin-antitoxin stability system	-
GH913_RS03735	884234..884527	+	294	WP_154138447.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GH913_RS03740	884640..885260	+	621	WP_154138448.1	hypothetical protein	-
GH913_RS03745	885459..885800	+	342	WP_154138568.1	hypothetical protein	-
GH913_RS03750	885872..886069	+	198	WP_017158766.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-93)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-86)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10679.06 Da
• Isoelectric Point: 8.9188

>T143365 WP_017158383.1 NZ_CP046019:881146-881427 [Xanthomonas citri pv. malvacearum]
MRTIDRSSAFKRDYKREAKGQHRATLDDAIKPVLVALATDQPPDARYRDHDLSGDWAGYRECHIKPDLLLIYRKSDPDTL
RLARLGSHSELFG

Nucleotide

• Length: 282 bp

>T143365 NZ_CP061062:4973240-4973587 [Klebsiella pneumoniae]
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9719.10 Da
• Isoelectric Point: 5.6976

>AT143365 WP_017158384.1 NZ_CP046019:880890-881159 [Xanthomonas citri pv. malvacearum]
MSTTADTYVRARIDTATKERAASALEAMGLSISDAIRLLMLRIADEHRLPFDVKVPNTTTKKAIAELESGKGKKFANVDD
LMADLHADD

Nucleotide

• Length: 270 bp

>AT143365 NZ_CP061062:4973587-4973886 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Toxin

• AlphaFold DB: A0A7X9YU06

Antitoxin

• AlphaFold DB: A0A7X9UWY6