Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 619085..619446 Replicon chromosome
Accession NZ_CP046019
Organism Xanthomonas citri pv. malvacearum strain HD-1

Toxin (Protein)


Gene name EcnB Uniprot ID M4UGA1
Locus tag GH913_RS02630 Protein ID WP_005914328.1
Coordinates 619085..619219 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID H8FG64
Locus tag GH913_RS02635 Protein ID WP_003486606.1
Coordinates 619294..619446 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH913_RS02610 614222..615913 - 1692 WP_033479687.1 M20/M25/M40 family metallo-hydrolase -
GH913_RS02615 616105..617139 - 1035 WP_050554793.1 MBL fold metallo-hydrolase -
GH913_RS02620 617178..618467 - 1290 WP_005914329.1 tryptophan--tRNA ligase -
GH913_RS02625 618649..618858 - 210 WP_003486601.1 CsbD family protein -
GH913_RS02630 619085..619219 - 135 WP_005914328.1 entericidin A/B family lipoprotein Toxin
GH913_RS02635 619294..619446 - 153 WP_003486606.1 entericidin A/B family lipoprotein Antitoxin
GH913_RS02640 619553..620476 - 924 WP_005914327.1 arginase -
GH913_RS02645 620797..621249 + 453 WP_003486611.1 roadblock/LC7 domain-containing protein -
GH913_RS02650 621313..621672 + 360 WP_003486613.1 hypothetical protein -
GH913_RS02655 621769..622686 + 918 WP_033481739.1 hypothetical protein -
GH913_RS02660 622683..623225 + 543 WP_003486615.1 GTPase -
GH913_RS02665 623707..624390 + 684 WP_003486617.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4459.32 Da        Isoelectric Point: 9.3487

>T143364 WP_005914328.1 NZ_CP046019:c619219-619085 [Xanthomonas citri pv. malvacearum]
MKRAIVLLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T143364 NZ_CP061062:4947271-4947639 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5122.07 Da        Isoelectric Point: 8.7942

>AT143364 WP_003486606.1 NZ_CP046019:c619446-619294 [Xanthomonas citri pv. malvacearum]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT143364 NZ_CP061062:4947053-4947274 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2W7U6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YLX6

References