Detailed information of TA system TA143342

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4088706..4090389
• Replicon: chromosome
• Accession: NZ_CP046006
• Organism: Escherichia coli strain 1919D3

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: GJD95_RS21035
• Protein ID: WP_096310260.1
• Coordinates: 4089472..4090389 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: GJD95_RS21030
• Protein ID: WP_096310262.1
• Coordinates: 4088706..4089479 (+)
• Length: 258 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJD95_RS21015	4085394..4086647	+	1254	Protein_3784	protease Lon-related BREX system protein BrxL	-
GJD95_RS21020	4086766..4088115	+	1350	WP_024243516.1	phospholipase	-
GJD95_RS21025	4088291..4088622	-	332	Protein_3786	IS3 family transposase	-
GJD95_RS21030	4088706..4089479	+	774	WP_096310262.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
GJD95_RS21035	4089472..4090389	+	918	WP_096310260.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
GJD95_RS24140	4090683..4090850	+	168	WP_001356018.1	hypothetical protein	-
GJD95_RS21040	4090903..4091565	-	663	WP_000357928.1	hypothetical protein	-
GJD95_RS21045	4091569..4092276	-	708	WP_095885822.1	integrase arm-type DNA-binding domain-containing protein	-
GJD95_RS21055	4092743..4093762	+	1020	WP_001349988.1	NADPH-dependent aldehyde reductase Ahr	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimH / fimG / fimF / fimD / fimC / fimI / fimA / fimE / fimB	4059263..4092276	33013

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34905.98 Da
• Isoelectric Point: 4.7729

>T143342 WP_096310260.1 NZ_CP046006:4089472-4090389 [Escherichia coli]
MDKTSPYYRQVALLVRALPWVANESCFALKGGTAINLFIHDFPRLSVDIDLAWIPLESREVALPNVREALTRIAAELEAQ
TGIRAVLQTHNPDEMRIIVTTDDAQIKIEVSPVARGTLYPPQERDIVGAVEEEFGFAALPVVSLPDLYGGKLCAALDRQH
PRDFYDVKMLLDTQGIDRSIFNGFIAYLLSHNRPLSEVLNPRWKDITEPFQNEFSGMTFEEVSLEELKEVPERMLSALKT
HFTQQDFDFLLSFKRGEPDWNIAPEPRIQNLPAVQWKLRNIGQMSEEKRAQSLEKLEKVMTEWLR

Nucleotide

• Length: 918 bp

>T143342 NZ_CP061048:c90576-90271 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 258 a.a.
• Molecular weight: 29293.69 Da
• Isoelectric Point: 9.9889

>AT143342 WP_096310262.1 NZ_CP046006:4088706-4089479 [Escherichia coli]
MASKLNWLLQNTSPGSLVLQSWLTRNNISPSLAFKYAQNGWLIKLRAGVYARAGREPDWSDALWCLQNQLEAPVHLAGLS
SLSWQGRSHYLQLKQNQCWLSVENKAILPKWFKEFPGVEWLMVSALKLPDLDEKYRTELEVKGKRITASTPELAAYELLS
AVAQEISFEHAAELFQGLVNLNPRKVEKLLTLSQSVQTKRLYLFFASFYEHAWFKRIDTSKINLGSGNRQIVVNGKLNTQ
YQITVPENFTKKGISHG

Nucleotide

• Length: 774 bp

>AT143342 NZ_CP061048:c90796-90578 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT