143338

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3475483..3476320 Replicon chromosome
Accession NZ_CP046006
Organism Escherichia coli strain 1919D3

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag GJD95_RS18160 Protein ID WP_000227784.1
Coordinates 3475778..3476320 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag GJD95_RS18155 Protein ID WP_001297137.1
Coordinates 3475483..3475794 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJD95_RS18130 3470503..3471450 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
GJD95_RS18135 3471472..3473463 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
GJD95_RS18140 3473453..3474067 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
GJD95_RS18145 3474067..3474396 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
GJD95_RS18150 3474408..3475298 + 891 WP_000971336.1 heme o synthase -
GJD95_RS18155 3475483..3475794 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
GJD95_RS18160 3475778..3476320 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
GJD95_RS18165 3476376..3477311 - 936 WP_001297127.1 sel1 repeat family protein -
GJD95_RS18170 3477719..3479083 + 1365 WP_040079362.1 MFS transporter -
GJD95_RS18175 3479211..3479702 - 492 WP_001138904.1 nucleotide binding protein YajQ -
GJD95_RS18180 3479870..3480781 + 912 WP_040079361.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T143338 WP_000227784.1 NZ_CP046006:3475778-3476320 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

>T143338 NZ_CP061041:c1348919-1348665 [Staphylococcus warneri]
ATGGCAATAGTATCGTACTCAATAGCTAGAAAAAATTTTAGAAGTTTAATAGATAAAGTTAACAATGATTCAGATGCGGT
GACTATAACAACTAATGATAGCAATGCTGTACTGATTTCGGAGTCAGATTACAATGCGATGATGGAGACATTATACCTCC
AACAATCCCCTGCTAATGCGCAACACTTGGCTAAATCTATAGAAGATGTTGAGCGTGGAAATACAATAGAGGTAGATTTA
GAATCATATGAGTAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT143338 WP_001297137.1 NZ_CP046006:3475483-3475794 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT143338 NZ_CP061041:c1348672-1348409 [Staphylococcus warneri]
ATGAGTAGATTAAATATTTTATTTACACCTGATGCATTTGAAGATTATAAATATTGGCAAATTCATGATAAAAAATTATT
AAAAAAGATTAACCATTTAATAAAATGTATAAATCGTAATGGCCCACTCGAAGGTGAAGGAAAACCTGAAGCTTTGAAAG
GTAATTTTAAGGGATATTATAGTAGAAGAATCAATTTTGAACATAGGTTAGTTTATAAAGTACATGATTCAGAAATAATT
ATTGTTTCTTGTAAATATCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References