Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 36275..36797 Replicon plasmid p1916D6-2
Accession NZ_CP046002
Organism Escherichia coli strain 1916D6

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag GJD94_RS00605 Protein ID WP_000220560.1
Coordinates 36516..36797 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag GJD94_RS00600 Protein ID WP_000121743.1
Coordinates 36275..36526 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJD94_RS00570 31638..31868 + 231 WP_000051064.1 partitioning protein -
GJD94_RS00575 31884..32177 + 294 WP_015060510.1 hypothetical protein -
GJD94_RS00580 32179..33147 + 969 WP_000654804.1 IS5-like element IS903B family transposase -
GJD94_RS00585 33207..33629 - 423 WP_195686758.1 DNA distortion polypeptide 3 -
GJD94_RS00590 33697..34143 - 447 Protein_39 hypothetical protein -
GJD94_RS00595 34183..35019 - 837 WP_001050931.1 replication initiation protein -
GJD94_RS00600 36275..36526 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
GJD94_RS00605 36516..36797 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJD94_RS00610 36943..37266 + 324 WP_001181903.1 hypothetical protein -
GJD94_RS00615 37311..37556 + 246 WP_000356546.1 hypothetical protein -
GJD94_RS00620 37546..37761 + 216 WP_001180116.1 hypothetical protein -
GJD94_RS00625 37854..38183 + 330 WP_000866648.1 hypothetical protein -
GJD94_RS23605 38470..38619 + 150 WP_000003880.1 hypothetical protein -
GJD94_RS00630 38632..38904 + 273 WP_000160399.1 hypothetical protein -
GJD94_RS00635 39231..39776 + 546 WP_038976855.1 hypothetical protein -
GJD94_RS00640 39779..40936 + 1158 WP_000538023.1 hypothetical protein -
GJD94_RS00645 41297..41788 + 492 WP_000872475.1 transcription termination factor NusG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaSHV-12 / tet(A) / floR / tet(X4) / lnu(F) / aadA2 - 1..59351 59351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T143295 WP_000220560.1 NZ_CP046002:36516-36797 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T143295 NZ_CP060989:59648-59800 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT143295 WP_000121743.1 NZ_CP046002:36275-36526 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT143295 NZ_CP060989:c59593-59536 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References