Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1374588..1375213 Replicon chromosome
Accession NZ_CP046000
Organism Escherichia coli strain 1916D18

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag GJD92_RS07300 Protein ID WP_000911329.1
Coordinates 1374815..1375213 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag GJD92_RS07295 Protein ID WP_000450524.1
Coordinates 1374588..1374815 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJD92_RS07270 1370390..1370860 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
GJD92_RS07275 1370860..1371432 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
GJD92_RS07280 1371578..1372456 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
GJD92_RS07285 1372473..1373507 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
GJD92_RS07290 1373720..1374433 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
GJD92_RS07295 1374588..1374815 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
GJD92_RS07300 1374815..1375213 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
GJD92_RS07305 1375360..1376223 + 864 WP_001267498.1 neutral zinc metallopeptidase -
GJD92_RS07310 1376238..1378253 + 2016 WP_000829393.1 tRNA cytosine(34) acetyltransferase TmcA -
GJD92_RS07315 1378327..1379025 + 699 WP_000679812.1 esterase -
GJD92_RS07320 1379135..1379335 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T143276 WP_000911329.1 NZ_CP046000:1374815-1375213 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T143276 NZ_CP060987:721965-722261 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT143276 WP_000450524.1 NZ_CP046000:1374588-1374815 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT143276 NZ_CP060987:722263-722658 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References