Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 298135..298766 Replicon chromosome
Accession NZ_CP046000
Organism Escherichia coli strain 1916D18

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag GJD92_RS02060 Protein ID WP_001259385.1
Coordinates 298135..298410 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag GJD92_RS02065 Protein ID WP_000593554.1
Coordinates 298407..298766 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJD92_RS02045 293139..294206 + 1068 WP_000361467.1 HlyD family secretion protein -
GJD92_RS02050 294203..296938 + 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -
GJD92_RS02055 296938..298062 + 1125 WP_025650299.1 ABC transporter permease -
GJD92_RS02060 298135..298410 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
GJD92_RS02065 298407..298766 + 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GJD92_RS02070 298816..299676 - 861 WP_001131783.1 class II aldolase -
GJD92_RS02075 299708..299977 - 270 WP_000933060.1 HPr family phosphocarrier protein -
GJD92_RS02080 299967..301475 - 1509 WP_001298718.1 carbohydrate kinase -
GJD92_RS02085 301468..302826 - 1359 WP_001298729.1 PTS galactitol transporter subunit IIC -
GJD92_RS02090 302903..303184 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
GJD92_RS02095 303181..303654 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 277297..305025 27728


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T143270 WP_001259385.1 NZ_CP046000:298135-298410 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T143270 NZ_CP060983:2688-2969 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTTGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATATGCGCTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT143270 WP_000593554.1 NZ_CP046000:298407-298766 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT143270 NZ_CP060983:2447-2698 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References