Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 23550..24109 Replicon plasmid p1916D18-2
Accession NZ_CP045999
Organism Escherichia coli strain 1916D18

Toxin (Protein)


Gene name relE Uniprot ID A0A1V2T4U7
Locus tag GJD92_RS00450 Protein ID WP_063073486.1
Coordinates 23834..24109 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1V2T5E1
Locus tag GJD92_RS00445 Protein ID WP_062894229.1
Coordinates 23550..23834 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJD92_RS00435 20858..21418 - 561 WP_001161490.1 recombinase family protein -
GJD92_RS00440 21728..23305 + 1578 WP_001513488.1 PAS domain-containing methyl-accepting chemotaxis protein -
GJD92_RS00445 23550..23834 + 285 WP_062894229.1 ribbon-helix-helix domain-containing protein Antitoxin
GJD92_RS00450 23834..24109 + 276 WP_063073486.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJD92_RS00455 24376..24864 - 489 Protein_21 transposase -
GJD92_RS00460 25012..25324 - 313 Protein_22 IS66 family insertion sequence element accessory protein TnpB -
GJD92_RS00470 27175..28311 + 1137 WP_033804283.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) - 1..78498 78498
- inside IScluster/Tn tet(A) - 12400..53688 41288


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10724.40 Da        Isoelectric Point: 9.8136

>T143267 WP_063073486.1 NZ_CP045999:23834-24109 [Escherichia coli]
MELKWTSKALSDLARLYDFLALASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIYAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T143267 NZ_CP060980:85764-86162 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10486.95 Da        Isoelectric Point: 5.6558

>AT143267 WP_062894229.1 NZ_CP045999:23550-23834 [Escherichia coli]
MQMKNNTAQVTKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLGTDNPLPVPR

Download         Length: 285 bp

>AT143267 NZ_CP060980:85537-85764 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V2T4U7

Antitoxin

Source ID Structure
AlphaFold DB A0A1V2T5E1

References