Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 36277..36799 Replicon plasmid p1916D18-1
Accession NZ_CP045998
Organism Escherichia coli strain 1916D18

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag GJD92_RS00210 Protein ID WP_000220560.1
Coordinates 36518..36799 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag GJD92_RS00205 Protein ID WP_000121743.1
Coordinates 36277..36528 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJD92_RS00175 31640..31870 + 231 WP_000051064.1 partitioning protein -
GJD92_RS00180 31886..32179 + 294 WP_015060510.1 hypothetical protein -
GJD92_RS00185 32181..33149 + 969 WP_195714615.1 IS5 family transposase -
GJD92_RS00190 33209..33631 - 423 WP_031942371.1 DNA distortion polypeptide 3 -
GJD92_RS00195 33699..34145 - 447 WP_001074386.1 hypothetical protein -
GJD92_RS00200 34185..35021 - 837 WP_001050931.1 replication initiation protein -
GJD92_RS00205 36277..36528 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
GJD92_RS00210 36518..36799 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJD92_RS00215 36945..37268 + 324 WP_001181903.1 hypothetical protein -
GJD92_RS00220 37313..37558 + 246 WP_000356546.1 hypothetical protein -
GJD92_RS00225 37548..37763 + 216 WP_001180116.1 hypothetical protein -
GJD92_RS00230 37856..38185 + 330 WP_000866648.1 hypothetical protein -
GJD92_RS23870 38472..38621 + 150 WP_000003880.1 hypothetical protein -
GJD92_RS00235 38634..38906 + 273 WP_000160399.1 hypothetical protein -
GJD92_RS00240 39233..39778 + 546 WP_038976855.1 hypothetical protein -
GJD92_RS00245 39781..40938 + 1158 WP_000538023.1 hypothetical protein -
GJD92_RS00250 41299..41790 + 492 WP_000872475.1 transcription termination factor NusG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaSHV-12 / tet(A) / floR / tet(X4) / lnu(F) / aadA2 - 1..59353 59353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T143266 WP_000220560.1 NZ_CP045998:36518-36799 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T143266 NZ_CP060980:c76808-76659 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT143266 WP_000121743.1 NZ_CP045998:36277-36528 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT143266 NZ_CP060980:76852-76913 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References