Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 2176149..2176732 Replicon chromosome
Accession NZ_CP045995
Organism Burkholderia sp. MS389

Toxin (Protein)


Gene name vapC Uniprot ID A0A8E2MX92
Locus tag GJG85_RS26130 Protein ID WP_050017907.1
Coordinates 2176352..2176732 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GJG85_RS26125 Protein ID WP_089489987.1
Coordinates 2176149..2176355 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJG85_RS26095 2171359..2171694 - 336 WP_089490028.1 type I toxin-antitoxin system SymE family toxin -
GJG85_RS26100 2172377..2172724 + 348 WP_050017913.1 metalloregulator ArsR/SmtB family transcription factor -
GJG85_RS26105 2172746..2173240 + 495 WP_089489983.1 arsenate reductase ArsC -
GJG85_RS26110 2173306..2174403 + 1098 WP_089489984.1 ACR3 family arsenite efflux transporter -
GJG85_RS26115 2174400..2175122 + 723 WP_089489985.1 arsenical resistance protein ArsH -
GJG85_RS26120 2175370..2176041 + 672 WP_089489986.1 NAAT family transporter -
GJG85_RS26125 2176149..2176355 + 207 WP_089489987.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GJG85_RS26130 2176352..2176732 + 381 WP_050017907.1 type II toxin-antitoxin system VapC family toxin Toxin
GJG85_RS26135 2176791..2177627 - 837 WP_050017906.1 ion transporter -
GJG85_RS26140 2177714..2178676 - 963 WP_050017905.1 LysR family transcriptional regulator -
GJG85_RS26145 2178833..2180008 + 1176 WP_204383987.1 amidohydrolase -
GJG85_RS26150 2180079..2180873 + 795 WP_124631446.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2171039..2187457 16418


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14094.46 Da        Isoelectric Point: 5.6956

>T143264 WP_050017907.1 NZ_CP045995:2176352-2176732 [Burkholderia sp. MS389]
MNVLIDTSVWVDHFRNRNQTLFELLALDAVLMHPMVLGELACGTPPAPRLRTLNDLGLLQECNQASMSEVMAFVEREKLY
GMGCGLVDLTLLASTLITPGARFWTLDRRLAALADRFSVEFRPTSK

Download         Length: 381 bp

>T143264 NZ_CP060979:c3967859-3967572 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7585.73 Da        Isoelectric Point: 8.6603

>AT143264 WP_089489987.1 NZ_CP045995:2176149-2176355 [Burkholderia sp. MS389]
MRTTVTIDDDLYTKALQMAEPGMDKADLFREAIKTFVRVQAAKRLAALGGSMSGMADIPRRRQEPESQ

Download         Length: 207 bp

>AT143264 NZ_CP060979:c3967585-3967283 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References