Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1242380..1243607 Replicon chromosome
Accession NZ_CP045995
Organism Burkholderia sp. MS389

Toxin (Protein)


Gene name vapC Uniprot ID A0A8E2SVV5
Locus tag GJG85_RS21985 Protein ID WP_050012402.1
Coordinates 1243026..1243607 (+) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GJG85_RS21980 Protein ID WP_050012403.1
Coordinates 1242380..1242946 (+) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJG85_RS21960 1238409..1239140 - 732 WP_050012407.1 ribonuclease T2 -
GJG85_RS21965 1239268..1239858 - 591 WP_050012406.1 hypothetical protein -
GJG85_RS21970 1239952..1241355 - 1404 WP_050012405.1 hypothetical protein -
GJG85_RS21975 1241694..1242332 + 639 WP_204384409.1 hypothetical protein -
GJG85_RS21980 1242380..1242946 + 567 WP_050012403.1 helix-turn-helix domain-containing protein Antitoxin
GJG85_RS21985 1243026..1243607 + 582 WP_050012402.1 HD domain-containing protein Toxin
GJG85_RS21990 1244625..1245383 + 759 WP_060734313.1 hypothetical protein -
GJG85_RS21995 1245427..1246185 + 759 WP_060734312.1 DsbC family protein -
GJG85_RS22000 1246517..1247698 + 1182 WP_050012400.1 macrolide transporter subunit MacA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1225371..1246185 20814


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21286.91 Da        Isoelectric Point: 5.5831

>T143261 WP_050012402.1 NZ_CP045995:1243026-1243607 [Burkholderia sp. MS389]
MNPDTIHARLAFLREAERLKNVLRSGYTSAGRAESTAEHSWRLGLMALVFADALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTASLDRTLRDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPGFDYAFNLGY
GRRYTDATPLFSAIREIVDADTQRRIDTGGRRA

Download         Length: 582 bp

>T143261 NZ_CP060979:3453849-3454067 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 20517.51 Da        Isoelectric Point: 10.7005

>AT143261 WP_050012403.1 NZ_CP045995:1242380-1242946 [Burkholderia sp. MS389]
MTASPLHSFSLGPPLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPDERATAERLLAARIDSAGDRALARLIAG
SAGRMHLVCDLTHRLLASSPARAAEFSQPLSMLLGTSLWRYATPEIVRMEAALDPLGWHDRAGPPSVEFDTGANASRVVP
IRGSRCRWTRMTLSDGSAVRLVETLDAL

Download         Length: 567 bp

>AT143261 NZ_CP060979:3453449-3453823 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References