Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1010643..1011298 Replicon chromosome
Accession NZ_CP045995
Organism Burkholderia sp. MS389

Toxin (Protein)


Gene name vapC Uniprot ID A0A8E2SVD3
Locus tag GJG85_RS20935 Protein ID WP_050017416.1
Coordinates 1010643..1011062 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E2SVP9
Locus tag GJG85_RS20940 Protein ID WP_060733370.1
Coordinates 1011059..1011298 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJG85_RS20910 1006096..1006890 + 795 WP_050017421.1 AraC family transcriptional regulator -
GJG85_RS20915 1007073..1008005 + 933 WP_204384367.1 DMT family transporter -
GJG85_RS20920 1008207..1008755 + 549 WP_204384368.1 permease -
GJG85_RS20925 1008850..1008984 - 135 WP_050017418.1 entericidin A/B family lipoprotein -
GJG85_RS20930 1009208..1010503 + 1296 WP_050017417.1 aspartate carbamoyltransferase -
GJG85_RS20935 1010643..1011062 - 420 WP_050017416.1 type II toxin-antitoxin system VapC family toxin Toxin
GJG85_RS20940 1011059..1011298 - 240 WP_060733370.1 Arc family DNA-binding protein Antitoxin
GJG85_RS20945 1011620..1013863 + 2244 WP_204384369.1 TonB-dependent siderophore receptor -
GJG85_RS20950 1013867..1014622 + 756 WP_204384370.1 sel1 repeat family protein -
GJG85_RS20955 1014619..1015302 + 684 WP_089489533.1 Fe2+-dependent dioxygenase -
GJG85_RS20960 1015388..1015627 + 240 WP_021158157.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GJG85_RS20965 1015624..1016019 + 396 WP_089489765.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(6-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14917.14 Da        Isoelectric Point: 5.1832

>T143260 WP_050017416.1 NZ_CP045995:c1011062-1010643 [Burkholderia sp. MS389]
MILVDTNVISEPLRREPSAAVIEWLDAQNVDTLFVAAISLAEIRFGVAVLPVGRRRDWLEQSIEQRVVPLFRGRILPFDD
AASKAYASLRAKARGTGNAMASADGFIAATAAANGLIVATRDVAPFEAAGLRVIDPWAS

Download         Length: 420 bp

>T143260 NZ_CP060979:2632831-2632938 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8849.08 Da        Isoelectric Point: 6.4685

>AT143260 WP_060733370.1 NZ_CP045995:c1011298-1011059 [Burkholderia sp. MS389]
MPMITVRNLPDEVHRALRIRAAQHGRSTEAEVRDILEQAVRPGGRLRLGTLLAEIGREAGGIDFEVQRDKTPTDPMSFE

Download         Length: 240 bp

>AT143260 NZ_CP060979:c2632784-2632718 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References