Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 901503..903262 Replicon chromosome
Accession NZ_CP045995
Organism Burkholderia sp. MS389

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag GJG85_RS20425 Protein ID WP_204384328.1
Coordinates 902360..903262 (-) Length 301 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8E2N168
Locus tag GJG85_RS20420 Protein ID WP_050011922.1
Coordinates 901503..902363 (-) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJG85_RS20400 896672..898162 - 1491 WP_176015794.1 aldehyde dehydrogenase -
GJG85_RS20405 898235..899056 - 822 WP_050011919.1 aspartate dehydrogenase -
GJG85_RS20410 899049..900716 - 1668 WP_050011920.1 thiamine pyrophosphate-binding protein -
GJG85_RS20415 900709..901506 - 798 WP_050011921.1 SDR family oxidoreductase -
GJG85_RS20420 901503..902363 - 861 WP_050011922.1 IclR family transcriptional regulator Antitoxin
GJG85_RS20425 902360..903262 - 903 WP_204384328.1 alpha/beta hydrolase Toxin
GJG85_RS20430 903281..903808 - 528 WP_006489904.1 cupin domain-containing protein -
GJG85_RS20435 903843..904613 - 771 WP_204384330.1 SDR family oxidoreductase -
GJG85_RS20440 904606..905676 - 1071 WP_089489495.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
GJG85_RS20445 905740..906051 - 312 WP_050011926.1 hypothetical protein -
GJG85_RS20450 906053..906370 - 318 WP_050011927.1 non-heme iron oxygenase ferredoxin subunit -
GJG85_RS20455 906815..907894 + 1080 WP_204384332.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-281)

Antitoxin

Transcription regulator IclR, N-terminal

(25-73)


Sequences

Toxin        


Download         Length: 301 a.a.        Molecular weight: 30995.30 Da        Isoelectric Point: 8.0452

>T143259 WP_204384328.1 NZ_CP045995:c903262-902360 [Burkholderia sp. MS389]
MSVIDKRERERDRTAAFAALLGQFPEQRCEAGAAGTIGYREAGAQLAGRTLPVVLLHGIGSGAASWVRQLDTLGASRRVL
AWDAPGYGVSTPVRGASPAAADYAASLNAWLDALGIERCVLVGHSLGAIIAGGLARVMPARIAGLLLISPAGGYGGAPAD
TRESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRIAVA
VGANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDGFCRQCDGQRGRE

Download         Length: 903 bp

>T143259 NZ_CP060979:2632296-2632403 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31454.89 Da        Isoelectric Point: 6.3943

>AT143259 WP_050011922.1 NZ_CP045995:c902363-901503 [Burkholderia sp. MS389]
MSEPLQHQQDADNAKTEAGYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNY
KLGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHG
HVLMGDLSLNELHALYPEGALNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTV
PRPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR

Download         Length: 861 bp

>AT143259 NZ_CP060979:c2632249-2632183 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References