Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 721935..722572 | Replicon | chromosome |
Accession | NZ_CP045993 | ||
Organism | Bacillus velezensis strain LABIM22 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | G4NU33 |
Locus tag | GJS30_RS03615 | Protein ID | WP_003156187.1 |
Coordinates | 722222..722572 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | I2HMS5 |
Locus tag | GJS30_RS03610 | Protein ID | WP_003156188.1 |
Coordinates | 721935..722216 (+) | Length | 94 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GJS30_RS03590 | 718300..718899 | - | 600 | WP_053573675.1 | rhomboid family intramembrane serine protease | - |
GJS30_RS03595 | 718992..719357 | + | 366 | WP_014304402.1 | holo-ACP synthase | - |
GJS30_RS03600 | 719522..720529 | + | 1008 | WP_021495080.1 | outer membrane lipoprotein carrier protein LolA | - |
GJS30_RS03605 | 720646..721815 | + | 1170 | WP_053285486.1 | alanine racemase | - |
GJS30_RS03610 | 721935..722216 | + | 282 | WP_003156188.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
GJS30_RS03615 | 722222..722572 | + | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
GJS30_RS03620 | 722690..723511 | + | 822 | WP_003156182.1 | STAS domain-containing protein | - |
GJS30_RS03625 | 723516..723881 | + | 366 | WP_003156180.1 | RsbT antagonist protein RsbS | - |
GJS30_RS03630 | 723884..724285 | + | 402 | WP_003156178.1 | anti-sigma regulatory factor | - |
GJS30_RS03635 | 724297..725304 | + | 1008 | WP_007609589.1 | PP2C family protein-serine/threonine phosphatase | - |
GJS30_RS03640 | 725368..725697 | + | 330 | WP_003156176.1 | anti-sigma factor antagonist RsbV | - |
GJS30_RS03645 | 725694..726176 | + | 483 | WP_007609591.1 | anti-sigma B factor RsbW | - |
GJS30_RS03650 | 726142..726930 | + | 789 | WP_003156171.1 | RNA polymerase sigma factor SigB | - |
GJS30_RS03655 | 726930..727532 | + | 603 | WP_007410234.1 | SpoIIE family protein phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T143255 WP_003156187.1 NZ_CP045993:722222-722572 [Bacillus velezensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T143255 NZ_CP060979:1999758-1999861 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 94 a.a. Molecular weight: 10562.92 Da Isoelectric Point: 6.4706
>AT143255 WP_003156188.1 NZ_CP045993:721935-722216 [Bacillus velezensis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT143255 NZ_CP060979:c1999899-1999628 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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