Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4729118..4729634 Replicon chromosome
Accession NZ_CP045988
Organism Klebsiella pneumoniae strain WCHKP35

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag CEA74_RS22955 Protein ID WP_009486548.1
Coordinates 4729118..4729402 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CEA74_RS22960 Protein ID WP_002886901.1
Coordinates 4729392..4729634 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEA74_RS22930 (4724535) 4724535..4724798 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
CEA74_RS22935 (4724928) 4724928..4725101 + 174 WP_002886906.1 hypothetical protein -
CEA74_RS22940 (4725104) 4725104..4725847 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CEA74_RS22945 (4726204) 4726204..4728342 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
CEA74_RS22950 (4728650) 4728650..4729114 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CEA74_RS22955 (4729118) 4729118..4729402 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CEA74_RS22960 (4729392) 4729392..4729634 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CEA74_RS22965 (4729712) 4729712..4731622 - 1911 WP_009486549.1 PRD domain-containing protein -
CEA74_RS22970 (4731645) 4731645..4732799 - 1155 WP_020316350.1 lactonase family protein -
CEA74_RS22975 (4732866) 4732866..4733606 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T143250 WP_009486548.1 NZ_CP045988:c4729402-4729118 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T143250 NZ_CP060979:832503-832910 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT143250 WP_002886901.1 NZ_CP045988:c4729634-4729392 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT143250 NZ_CP060979:832256-832522 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References