Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 807595..808252 Replicon chromosome
Accession NZ_CP045988
Organism Klebsiella pneumoniae strain WCHKP35

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag CEA74_RS03970 Protein ID WP_002916310.1
Coordinates 807842..808252 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag CEA74_RS03965 Protein ID WP_002916312.1
Coordinates 807595..807861 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEA74_RS03940 (802751) 802751..804184 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
CEA74_RS03945 (804303) 804303..805031 - 729 WP_009485882.1 MurR/RpiR family transcriptional regulator -
CEA74_RS03950 (805081) 805081..805392 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
CEA74_RS03955 (805556) 805556..806215 + 660 WP_002916317.1 hemolysin III family protein -
CEA74_RS03960 (806366) 806366..807349 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
CEA74_RS03965 (807595) 807595..807861 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
CEA74_RS03970 (807842) 807842..808252 + 411 WP_002916310.1 protein YgfX Toxin
CEA74_RS03975 (808259) 808259..808780 - 522 WP_002916308.1 flavodoxin FldB -
CEA74_RS03980 (808881) 808881..809777 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
CEA74_RS03985 (809800) 809800..810513 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CEA74_RS03990 (810519) 810519..812252 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T143237 WP_002916310.1 NZ_CP045988:807842-808252 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T143237 NZ_CP060974:3784668-3784946 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT143237 WP_002916312.1 NZ_CP045988:807595-807861 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT143237 NZ_CP060974:3784405-3784665 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References